Acrolein and embryogenesis: An experimental study

Chhibber, Geeta; Gilani, Shamshad H.

doi:10.1016/s0013-9351(86)80006-8

Cited by 8 publications

(2 citation statements)

References 7 publications

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“…Acrolein is a dermal, ocular, and respiratory irritant. It interferes with cell mitosis (Chhibber and Gilani 1986) and is a thiol-reactive compound (Dypbukt et al 1993). Reduced glutathione (GSH) plays a major role in the maintenance of mitochondrial thiol status (Smith et al 1996).…”

mentioning

confidence: 99%

Acrolein-Induced Toxicity—Defective Mitochondrial Function as a Possible Mechanism

Arumugam

Thanislass²,

Ragunath

et al. 1999

Arch. Environ. Contam. Toxicol.

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Administration of acrolein (2.5 mg/kg body weight/day) to rats for 45 days depleted the glutathione level in liver, which triggered an imbalance in the antioxidant defense, resulting in lipid peroxidation. Enhanced lipid peroxidation damaged the membranous structure of mitochondria, which was indicated by the loss of lamellae, and increased the oxidation of exogenously added NADH. Loss in membrane integrity altered the activities of the tricarboxylic acid cycle enzymes and levels of cytochromes. Decreased rate of ADP-stimulated oxygen uptake, respiratory coupling ratio, and ATP synthesis-were also observed. We report that the acrolein-induced toxicity is mediated through the depletion of GSH leading to impairment of rat liver mitochondrial function.

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mentioning

confidence: 99%

Acrolein-Induced Toxicity—Defective Mitochondrial Function as a Possible Mechanism

Arumugam

Thanislass²,

Ragunath

et al. 1999

Arch. Environ. Contam. Toxicol.

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“…Rat, mouse, and chicken embryos cultured with acrolein show inhibition of cell blastulation (260)(261)(262). Similar lethality and teratogenicity occurred when acrolein was administered to pregnant rats intra-amniotically (260) and to rabbits intravenously prior to insemination (250).…”

Section: Reproductive and Developmentalmentioning

confidence: 94%

Aldehydes and Acetals

Borchers¹

2012

Patty's Toxicology

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More than 300 aldehydes occur in foods, water, and air. Due to the electrophilicity of the carbonyl carbon, particularly when proximal to a carbon–carbon double bond, aldehydes react with thiols and amines to form protein–protein, DNA–protein, and DNA–DNA cross‐links. Despite their potential for causing cell damage, toxicological and exposure data for a large number of aldehydes are lacking. Inhalation and ingestion studies have demonstrated that a number of aldehydes are irritants and can induce tumors in animal models. Formaldehyde, which is a suspected carcinogen, is the most widely studied of these compounds. The physicochemical properties of saturated aldehydes are summarized. Toxicological and health effects are given.

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Aldehydes and Acetals

Morandi¹,

Maberti²

2001

Patty's Toxicology

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More than 300 aldehydes occur in foods, water, and air. Due to the electrophilicity of the carbonyl carbon, particularly when proximal to a carbon–carbon double bond, aldehydes react with thiols and amines to form protein–protein, DNA–protein, and DNA–DNA cross‐links. Despite their potential for causing cell damage, toxicological and exposure data for a large number of aldehydes are lacking. Inhalation and ingestion studies have demonstrated that a number of aldehydes are irritants and can induce tumors in animal models. Formaldehyde which is a suspected carcinogen is the most widely studied of these compounds. The physicochemical properties of saturated aldehydes are summarized. Toxicological and health effects are presented.

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Acrolein and embryogenesis: An experimental study

Cited by 8 publications

References 7 publications

Acrolein-Induced Toxicity—Defective Mitochondrial Function as a Possible Mechanism

Acrolein-Induced Toxicity—Defective Mitochondrial Function as a Possible Mechanism

Aldehydes and Acetals

Aldehydes and Acetals

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