Acrokeratosis-verruciformis-ähnliche Veränderungen beim Morbus Darier

Abstract

In the literature, a number of observers reported that acrokeratosis verruciformis (Hopf) often evolves in cases of keratosis follicularis. The relationship of these verruciform manifestations to keratosis follicularis is discussed. In this paper, we present three patients with Darier's disease, who have verruciform papules on the dorsal surfaces of the hands and feet. Histopathologically, the papules showed the distinctive structures of Darier's disease. Therefore, these lesions are regarded as an abortive form of keratosis follicularis. It is necessary to examine carefully the punch biopsies histomorphologically. We also recommend having a closer look at the development of other typical Darier's skin lesions in the follow-up of patients.

A Case of Acral Darier’s Disease

“…Three other cases were described by Regazzini et al [4]: a 42-year-old woman with keratotic papules and pits of the hands and feet and haemorrhagic macules on the fingers, her 38-year-old sister with palmoplantar pits associated with haemorrhagic macules on the hands and the former’s 12-year-old daughter with hyperkeratotic papules on the extensor surface of the arms and haemorrhagic macules on the hands and fingers. Hafner and Vakilzadeh [7]reported 3 patients with verruciform papules on the dorsum of the hands and feet.…”

“…Sometimes the disease begins at the extremities and speads to the typical areas. Rarely it is limited to the acral regions; only few such cases have been described [3, 4, 5, 6, 7]. The disease has a chronic course, manifesting itself between the ages of 5 and 10 years, with a peak at puberty.…”

Fokale akrale Hyperkeratose

“…Weitere Differentialdiagnosen der fokalen akralen Hyperkeratose sind die Keratoelastoidosis marginalis der Hände [1,20] [12].…”

Intertrigin�se akantholytische Dyskeratose

“…verruciformis Hopf entsprechen [16]. An Handflächen, Fingerbeeren und Fußsohlen finden sich punktförmige Unterbrechungen der Papillarlinien, die nicht selten bei der Inspektion übersehen werden [4].…”