Acrokeratosis Paraneoplastica (Bazex Syndrome): A Case Report

Abstract

Acrokeratosis paraneoplastica Bazex is a rare paraneoplastic skin manifestation, typically causing acral psoriasiform lesions. Patients usually show erythematous hyperkeratosis with yellowish, adherent scales on the hands and feet or other acral locations such as ears or nose. We herein report a case of Bazex syndrome in a male patient, who was previously diagnosed with hepatocellular carcinoma. Our case report highlights this rare condition as early diagnosis may impact the patient’s course of tumor disease and prognosis.

Bazex Syndrome (Acrokeratosis Paraneoplastica): A Narrative Review of Pathogenesis, Clinical Manifestations, and Therapeutic Approaches

“…The clinical manifestations often include plaques that vary in color from reddish to bluish-purple with noticeable scaling [ 10 ]. This scaling superficially resembles psoriasis; however, the lesions in Bazex syndrome may occur in regions uncommonly associated with psoriasis vulgaris [ 11 ].…”

“…Despite the general consistency in the symptomatology of Bazex syndrome across different cases, one noticeable disparity lies in the temporal relationship between skin manifestations and the appearance of the underlying malignancy symptoms [ 7 , 10 , 11 , 13 ]. The skin changes precede cancer symptoms by at least six months in a majority of cases, but this pattern does not apply universally.…”