Acrokeratoelastoidosis successfully treated with 10% salicylic acid ointment

Shiiya, Chihiro; Hata, Hiroo; Inamura, Yuka; Imafuku, Kimiaki; Kitamura, Shinya; Yanagi, Teruki; Fujita, Yasuyuki; Shimizu, Hiroshi

doi:10.1111/1346-8138.13503

Cited by 7 publications

(5 citation statements)

References 4 publications

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“…Since 1990, slightly more than two dozen cases of AKE have been reported. 6,7,[21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40] We reviewed twenty-four cases in the literature. The patients were also older with a median age of 36 years (range between 5 and 79 years old).…”

Section: Discussionmentioning

confidence: 99%

“…22,24,28,29 The duration between onset of lesions and presentation was quite varied, two cases had the lesions present from birth, two presented within months of onset while eleven cases had less than 10-year history. 6,21,22,[24][25][26][27][28][29][30][31]34,39,40 The ethnicity of eight cases was not given; however, African/dark-skin was reported in five of the remaining nineteen cases. 6,26,31,35,40 Family history was reported in only four cases.…”

Section: Discussionmentioning

confidence: 99%

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Marginal acrokeratoderma: a case series

Ibekwe

Ogunbiyi

2020

Int J Res Dermatol

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<p>Marginal acrokeratoderma (MAK) are complex disorders characterized by distribution of cornified papules/plaques along the dorso-plantar and dorso-palmar junction of the feet and hands. They belong to the family of punctate palmoplantar keratoderma. No associated gene defect has been detected. There are two clinically identical types of hereditary/familial MAK; namely acrokeratoelastoidosis (AKE) and focal acral hyperkeratosis (FAH); differentiated by the presence of elastorrehexis in AKE. The aim of this article is to report MPK lesions that are not included in the familiar groupings of punctate and polygonal papules. We described thirteen cases and reviewed the literature. Average age at presentation was 24 years, age ranged from 5 to 79 years. Majority of our cases had lesions on only their feet, that of FAH had lesions on only their hands and AKE had lesions on both hands and feet. Although most lesions reported in literature with FAH and AKE were characterized as 2-5mm flesh-colored to yellowish flat-topped/polygonal, keratotic/punctate papules, coalescing into plaques, we also reported lesions that were keratotic with cracks, desquamating and cobble-stone in appearance. This case series calls for more studies on variations in clinical presentation of MAK lesions and an opportunity to revisit the genetic basis and investigate triggers of this rare disorder.</p>

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Marginal acrokeratoderma: a case series

Ibekwe

Ogunbiyi

2020

Int J Res Dermatol

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“…La AqE generalmente no requiere tratamiento específico 19 . Se han intentado diversos métodos: la crioterapia, queratolíticos (como ácido salicílico) 20 , retinoides, corticoides orales y tópicos y láser Erbium YAG, entre otros, con resultados variables, siendo los retinoides orales con los que se consigue alguna mejoría, pero con recaída al suspenderlos 21,22 .…”

Section: Discussionunclassified

Acroqueratoelastoidosis de Costa: reporte de un caso esporádico

Ochoa

Contreras

Cárdenas

et al. 2019

MedUPB

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RESUMENLa acroqueratoelastoidosis de Costa es una rara genodermatosis autosómica dominante con expresividad variable, que se caracteriza por la presencia de múltiples pápulas hiperqueratósicas en la zona marginal de las manos, los pies o ambas. Debuta predominantemente en la niñez y vida adulta temprana, es de curso crónico y generalmente asintomática. Su diagnóstico diferencial del resto de las acroqueratodermias es un desafío para el clínico, sin embargo, el hallazgo histológico de elastorrexis nos permite categorizarla. Presentamos un caso esporádico de una paciente joven, con características clínicas e histopatológicas típicas de la enfermedad.

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“…13 Punctate palmoplantar keratoderma is an is an autosomal dominant genodermatosis that affects both palms and soles; histology shows marked hyperkeratosis, parakeratosis, and mild acanthosis without significant dermal changes. 14 Usually no treatment is required for AKE because lesions are benign and mostly asymptomatic, however topical 10% salicylic acid 15 , urea, calcipotriol and corticosteroids, systemic or topical retinoids, Nd-YAG and Er:YAG lasers 16 , cryosurgery and iontophoresis 1,7,17 have been tried with transient and minor benefits. In the case described, we first tried 8% salicylic acid, with no significant improvement, so we opted for an emollient cream with 5% urea.…”

Section: Acrokeratoelastoidosismentioning

confidence: 99%