“…22 Next, patients with AE may show a 'zebra-like' pattern of hair coloration, which seems to reflect changes of systemic zinc level, 38 and sometimes red 20,43 or yellow 23 coloration of hair, implying ongoing phaeomelanogenesis due to poor zinc supply; the hair colour returns to normal during treatment. 20,23,43 Sometimes not only dietary zinc, but even tyrosine (thus, all the intermediates of melanogenesis) deficiency may cause a transient red coloration of hair. 73 It urges one to check the quality of melanin in hair of patients with AE, the influence of zinc excess on hair coloration of mice on A Y /a and other genotype backgrounds, and to check systematically the effects of zinc deficiency on these murine models.…”