Acrodermatitis Enteropathica: A Lethal Inherited Human Zinc-Deficiency Disorder

Moynahan, E. J.

doi:10.1016/s0140-6736(74)91772-3

Cited by 543 publications

(194 citation statements)

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“…Acrodermatitis enteropathica (AE), a form of Zn deficiency (Moynahan, 1974) and malabsorption in humans, has been treated with diiodohydroxyquin (a chelating agent) since 1953 (Dillaha et al, 1953). Acrodermatitis enteropathica is observed when infants who have been receiving human breast milk are weaned to cow milk or soy-based formulas.…”

Section: Introductionmentioning

confidence: 99%

Influence of Picolinic Acid on the Uptake of 65Zinc-Amino Acid Complexes by the Everted Rat Gut

Hill

Peo

Lewis

1987

Journal of Animal Science

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Three hundred fifty rats were used in three experiments to: 1) validate the everted gut procedure as an in vitro technique for estimating Zn absorption, 2) determine the effect of increasing ratios of picolinic acid (PA) to Zn on Zn absorption and 3) determine the effect of PA on absorption of Zn and amino acid complexes at pH 6, 7 and 8. In the first experiment the time delay between tissue collection with subsequent storage in ice-cold saline and start of tissue incubation was 0, 10, 20 or 30 min. A linear decrease was observed for 6s Zn uptake with increasing delay time. Lysine absorption was not affected by delay time. In the second experiment, molar ratios of PA:Zn of 0, .5, 1.0, 1.5, 2.0 and 2.5 with Zn held constant were evaluated. A linear decrease in 6s Zn absorption from 6s ZnCI: occurred as the molar ratio of PA to Zn increased. In the third experiment, 0 and 5 molar ratios of PA to a constant Zn level were evaluated using 6s ZnCI2, 6SZn-14C-methionine (ZnMet) and 6SZn-3H-lysine (ZnLys) at pH 6, 7 and 8. The addition of PA decreased Zn absorption regardless of Zn source. The data suggest that the Zn sources used were of similar biological value. The data do not support the theory that PA facilitates Zn absorption.

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Section: Introductionmentioning

confidence: 99%

Influence of Picolinic Acid on the Uptake of 65Zinc-Amino Acid Complexes by the Everted Rat Gut

Hill

Peo

Lewis

1987

Journal of Animal Science

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“…Adicionalmente, más de la mitad de estos niños también tienen diarrea intermitente (4). Se ha observado que los síntomas de la acrodermatitis enteropática desaparecen si se administran grandes dosis de zinc (5).…”

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El Zinc en La Salud Humana - Ii

Romaña

Diazgranados

2010

Rev. chil. nutr.

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de zinc se puede originar como resultado de una ingesta dietética inadecuada, especialmente en periodos que aumentan los requerimientos, como en periodos de crecimiento rápido (infancia y adolescencia), por malabsorción, por el incremento de las pérdidas y/o por impedimentosd en su utilización (1). Sin embargo, en la mayoría de los casos la causa primaria de deficiencia de zinc es una ingesta inadecuada del zinc absorbible, la cual comúnmente ocurre como resultado de la combinación de una baja ingesta dietética y el consumo frecuente de alimentos con bajo contenido de este elemento y/o de formas de zinc poco absorbibles (1).Se ha estimado que aproximadamente un tercio de la población mundial vive en países identificados por tener un alto riesgo de deficiencia de zinc (2) (figura 1). Los grupos que se encuentran en alto riesgo de ser deficientes en zinc son: a) lactantes nacidos pre-término, b) lactantes pequeños para su edad gestacional, c) los niños en la etapa de destete, d) los niños en recuperación de una desnutrición, e) los adolescentes, f) las mujeres ABSTRACT Zinc is a divalent cation with multiple functions in the human body. Zinc absorption occurs in the small intestine and is, together with its excretion via faeces, the point of control for zinc homeostasis. Zinc is an essential nutrient with a specific role in more than 300 enzymes which participate in all important biochemical reactions of the human body. Therefore, zinc status has a direct effect in growth, neurological and behavioural development and in the immune system. The diagnosis of zinc deficiency in individuals is not yet possible given that there still is no indicator with adequate sensitivity. Nevertheless, it is acceptable to use serum zinc levels to evaluate populations. Finally, intervention strategies such as supplementation, food fortification and/or dietary modification can be used to control and/or prevent zinc deficiency.

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“…This disease can be cured or prevented by giving relatively large amounts of Zn by mouth (9). Acrodermatitis enteropathica, a childhood disease of high morbidity and mortality that is transmitted genetically as an autosomal recessive trait and is associated with characteristic skin disease, bowel and central nervous system malfunction, and frequent immunodeficiency, is also completely correctable by administration of zinc (10,11). In rats, zinc deficiency regularly leads to experimental acrodermatitis enteropathica and atrophy of lymphoid tissue and thymus, which can be promptly corrected by administration of zinc (12).…”

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confidence: 99%