Acrodermatitis chronica atrophicans mit fibroiden Knoten und monoklonale Gammopathie

Goos, M.; Roelcke, D.; Schnyder, U. W.

doi:10.1007/bf00595365

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…Different Borrelia strains have been variably associated with primary cutaneous lymphomas [1]. This The Oncologist ® Lymphoma association has been suggested by the correlation occurring between acrodermatitis chronica atrophicans, a cutaneous manifestation of Lyme disease, and cutaneous B-cell lymphomas, and confirmed by serologic tests and molecular studies; these results are almost exclusively reported under the form of case studies or small retrospective series of primary and secondary cutaneous Bcell lymphomas [2][3][4][5][6][7]. B. burgdorferi DNA has been detected in 10%-42% of patients with cutaneous mucosa-associated lymphoma tissue (MALT) lymphomas, in 15%-26% of cases of cutaneous follicular and diffuse large B-cell lymphomas, and in 18% of mycosis fungoides diagnosed in some European countries [2, 3,7,8].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Borrelia Burgdorferi Infection in a Series of 98 Primary Cutaneous Lymphomas

Ponzoni

Ferreri²,

Mappa³

et al. 2011

The Oncologist

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Borrelia burgdorferi has been variably associated with different forms of primary cutaneous lymphoma. Differences in prevalence rates among reported studies could be a result of geographic variability or heterogeneity in the molecular approaches that have been employed. In the present study, we investigated the prevalence of Borrelia burgdorferi sensu lato DNA in diagnostic tissue samples from fresh cutaneous biopsies of 98 primary cutaneous lymphomas and 19 normal skin controls. Three different polymerase chain reaction (PCR) protocols targeting the hbb, flagellin, and Osp-A genes were used. Direct sequencing of both sense and antisense strands of purified PCR products confirmed the specificity of the amplified fragments. Sequence specificity was assessed using the Basic Local Alignment Search Tool, and MultAlin software was used to investigate the heterogeneity of target gene sequences across the different samples.Borrelia DNA was not detected in 19 controls, 23 cases of follicular lymphoma, 31 cases of extranodal marginal zone lymphoma, or 30 cases of mycosis fungoides. A single case of 14 diffuse large B-cell lymphoma cases was positive for B. burgdorferi.This study does not support a pathogenic role of B. burgdorferi in primary cutaneous B-and T-cell lymphomas from areas nonendemic for this microorganism and the consequent rationale for the adoption of antibiotic therapy in these patients. The Oncologist 2011;16:1582-1588

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