Acrocomia crispa fruits lipid extract prevents LPS-induced acute lung injury in mice

Mena, Licet; Guerra, Roxana; Valle, Maikel; Molina, Vivián; Rodríguez, S. M.; Merino, Nelsón; Zamora, Zullyt; González, Víctor L.; Medina, Juan Pablo

doi:10.35588/blacpma.19.18.1.02

Cited by 4 publications

(5 citation statements)

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“…Furthermore, this molecule also regulated inflammatory cytokines [ 63 ]. Similar results were found by Mena et al (2019) for a lipid extract of Acrocomia crispa fruits, which reduced mice lung edema and histological scores after LPS-induced mice lung injury [ 64 ]. Spengler et al (2017), on the other hand, conducted an in vivo study in a porcine ARDS model to investigate the anti-inflammatory effects of surfactant-derived phospholipids [ 75 ].…”

Section: Pharmaceutical Active Natural Products With Potential To Tresupporting

confidence: 87%

“…Reduction of histological score. [ 64 ] Lipoxygenase-derived eicosanoid Lipoxin A4 LPS-induced mice lung injury and in alveolar epithelial type II cells In vivo and in vitro LPS at 10 mg/kg was intratracheally administered to induce lung injury in mice following treatment with lipoxin A4 (10 μg/mouse). Cells were isolated from lungs of grossly normal appearance.…”

Section: Pharmaceutical Active Natural Products With Potential To Trementioning

confidence: 99%

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Could natural products modulate early inflammatory responses, preventing acute respiratory distress syndrome in COVID-19-confirmed patients?

Amaral-Machado¹,

Oliveira²,

Rodrigues³

et al. 2021

Biomedicine & Pharmacotherapy

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Section: Pharmaceutical Active Natural Products With Potential To Tresupporting

confidence: 87%

Section: Pharmaceutical Active Natural Products With Potential To Trementioning

confidence: 99%

Could natural products modulate early inflammatory responses, preventing acute respiratory distress syndrome in COVID-19-confirmed patients?

Amaral-Machado¹,

Oliveira²,

Rodrigues³

et al. 2021

Biomedicine & Pharmacotherapy

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“…Nutraceutical studies have explored the use of acrocomia fruits as a complement to high-protein diets and the bioaccessibility of essential minerals contained in the pulp, identifying it as a potential source of Cu, Fe, Mn, and Zn with a high nutritional value (Almeida et al 2020;Gonçalves et al 2020). Furthermore, lipid extracts from A. crispa fruits were shown to have properties protecting against lung and kidney diseases in mice (Mena et al 2019;Oyarzábal-Yera et al 2019). The use of kernel and pulp cakes as animal feed is still under exploration, e.g., with regard to rumen degradability in sheep and inclusion of pulp cake in the diets of broilers and rabbits (Ferreira et al 2019a(Ferreira et al , 2019bNeta et al 2019).…”

Section: A Short History Of Acrocomia Researchmentioning

confidence: 99%

Acrocomia spp.: neglected crop, ballyhooed multipurpose palm or fit for the bioeconomy? A review

Vargas‐Carpintero

Hilger

Mössinger

et al. 2021

Agron. Sustain. Dev.

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Acrocomia spp., a genus of wild-growing palms in the neotropics, is rapidly gaining interest as a promising multipurpose crop. Diverse products can be derived from various components of the palm, the oils being of highest interest. Acrocomia shows similar oil yield and fatty acid composition to the African oil palm (Elaeis guineensis). It is, however, able to cope with a wider range of environmental conditions, including temporary water scarcity and lower temperatures, thus potentially a more sustainable alternative to its tropical counterpart. Acrocomia’s research history is recent compared to other traditional crops and thus knowledge gaps, uncertainty, and challenges need to be addressed. This review attempts to assess the acrocomia’s preparedness for cultivation by highlighting the state-of-the-art in research and identifying research gaps. Based on a systematic literature search following a value web approach, it (a) provides a comprehensive overview of research topics, (b) shows the development of publication activities over time and the drivers of this development, and (c) compiles main findings to assess the acrocomia’s preparedness for commercial cultivation. Our results confirm its multipurpose characteristic as a potential feedstock for manifold sectors. Research has continued to increase over the last decade, especially on A. aculeata and is driven by the interest in bioenergy. Increasing knowledge on botany has contributed to understanding the genetic diversity and genus-specific biology. This has enabled applied research on seed germination and propagation toward domestication and initial plantation activities, mostly in Brazil. Main research gaps are associated with genotype–environment interaction, planting material, crop management, and sustainable cropping systems. Overall, we conclude that acrocomia is at an early phase of development as an alternative and multipurpose crop and its up-scaling requires the integration of sustainability strategies tailored to location-based social-ecological conditions.

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“…In vitro , D-005 inhibited cyclooxygenase type 2 (COX-2) activity in the microsomal fraction of rat seminal vesicles and 5-lipoxygenase (5-LOX) activity in the cytosolic fraction of rat polymorphonuclear leukocytes [17]. In vivo , D-005 significantly attenuated neutrophil infiltration in lipopolysaccharide-induced acute lung injury in mice [18]. In addition, D-005 decreased prostate malondialde-hyde (MDA) and sulfhydryl (SH) group levels in rats with testosterone-induced prostatic hyperplasia [19].…”

Section: Introductionmentioning

confidence: 99%

Protective effects of D-005, a lipid extract from Acrocomia crispa fruits, against ischemia/reperfusion-induced acute kidney injury in rats

Oyarzábal-Yera

Rodríguez-Salgueiro

Merino-García

et al. 2019

Kidney Res Clin Pract

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BackgroundAcute kidney injury (AKI) induced by renal ischemia/reperfusion (IR) is associated with enhanced production of reactive oxygen species in renal tissues. D-005, a lipid extract obtained from Acrocomia crispa fruit, has previously shown antioxidant effects. The aim of this work was to evaluate the effects of D-005 on renal IR-induced AKI in rats.MethodsRats were randomized into seven groups including a negative control group (vehicle) without AKI and six groups with renal IR-induced AKI as follows: a positive control (vehicle); D-005 treatment at 25, 100, 200, or 400 mg/kg; and dexamethasone at 3 mg/kg. All treatments were orally administered as single doses 1 hour before AKI induction. Biomarkers (serum creatinine, urea, and uric acid concentrations), oxidative variables, and histopathological AKI changes were evaluated in blood and kidney tissues.ResultsAll D-005 doses protected against IR-induced AKI in rats by significantly decreasing biomarkers and histopathological AKI changes as assessed by reduced serum concentrations of creatinine, urea, and uric acid. In addition, all D-005 doses decreased tubular damage, as shown by fewer detached cells and casts in the tubular lumen. D-005 reversed oxidation disturbance markers by decreasing malondialdehyde and sulfhydryl group concentrations in plasma and in kidney homogenates and by increasing kidney catalase activity. Dexamethasone, the reference substance, protected against IR-induced AKI in rats by reducing biochemical and histological variables of renal damage in a similar manner.ConclusionAdministration of single oral doses of D-005 markedly and significantly protected against renal IR-induced AKI, possibly due to its known antioxidant effects.

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Acrocomia crispa fruits lipid extract prevents LPS-induced acute lung injury in mice

Abstract: Acrocomia crispa fruits lipid extract prevents LPS-induced acute lung injury in mice [Extracto lipídico de los frutos de Acrocomia crispa previene el daño pulmonar agudo inducido por LPS en ratones]

Cited by 4 publications

References 28 publications

Could natural products modulate early inflammatory responses, preventing acute respiratory distress syndrome in COVID-19-confirmed patients?

Could natural products modulate early inflammatory responses, preventing acute respiratory distress syndrome in COVID-19-confirmed patients?

Acrocomia spp.: neglected crop, ballyhooed multipurpose palm or fit for the bioeconomy? A review

Protective effects of D-005, a lipid extract from Acrocomia crispa fruits, against ischemia/reperfusion-induced acute kidney injury in rats

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