Acrochordon-like basal cell carcinomas in patients with basal cell nevus syndrome

Lortscher, David N; Sengelmann, Roberta D.; Allen, Shawn

doi:10.5070/d30039g7k0

Cited by 15 publications

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“… 24 , 31 Although the “nevoid” lesions imply the disease’s name, only a limited number of case reports are available, and the ratio of BCCs presenting with these features has not been evaluated previously. 16 , 21 , 22 , 24 , 30 , 31 Basal cell carcinoma lesions in the form of acrochordon (skin-tag) or dermal nevus-like, reflecting the early nevoid phase of Gorlin syndrome were frequently encountered in our series especially in the childhood period (45.4% in children and 15.7% in adults) ( Figure 1D - F ). Histopathological examination should be performed on acrochordon-like lesions in children because they may be the presenting sign of Gorlin syndrome.…”

Section: Discussionmentioning

confidence: 77%

“…In addition to classical subtypes, BCCs may also appear as soft pedunculated lesions in Gorlin syndrome that can be mistaken for acrochordons. 16 , 30 , 31 The “skin tags” of Gorlin syndrome were described by Nomland in 1932 and they represent the “nevi” of this syndrome. 4 , 22 , 32 In addition, “more than 10 basal cell naevi” was stated as a diagnostic criterion for Gorlin syndrome described by Evans et al in 1993.…”

Section: Discussionmentioning

confidence: 99%

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Gorlin Syndrome: A Comprehensive Evaluation of Skin Findings

Atcı,

Melnicova,

Baykal

2024

Turkish Archives of Pediatrics

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Objective: Although Gorlin syndrome has rich skin findings, there is limited information about their subtypes, features specific to this genodermatosis, and relationships with each other. Materials and Methods: The demographic characteristics as well as cutaneous and extracutaneous findings of consecutive Gorlin syndrome patients diagnosed during 23 years were evaluated retrospectively. The relationship between palmoplantar pitting and basal cell carcinoma (BCC) in this localization and the relationship between odontogenic keratocysts (OKCs) and epidermoid cysts were investigated. Results: A total of 30 patients were diagnosed with Gorlin syndrome of whom 36.7% were children. BCC was the most common finding (90%) followed by OKCs (83.3%), skeletal system anomalies (76.7%), and palmoplantar pitting (76.7%). While classical BCC (63.3%) lesions were the predominant clinical subtype among all patients, acrochordon-like or small-sized papular BCCs were seen in 45.4% of pediatric patients. Three patients, 2 of whom were children, had BCC lesions in the palmoplantar region in association with palmoplantar pitting. Epidermoid cysts presenting clinically as solitary (n = 12) or a few nodules (n = 4) without punctum, located more commonly in acral areas (n = 10) were seen in 16 (53.3%) patients of whom 7 were children. Epidermoid cysts were seen in 60% of patients with OKCs, and the relationship between epidermoid cysts and OKCs was not statistically significant ( P = .15). Extracutaneous tumors such as medulloblastoma (n = 3), cardiac fibroma (n = 1), and ameloblastoma (n = 1) were also recorded. Conclusion: The awareness of papular or acrochordon-like BCCs, palmoplantar BCCs, and acral epidermoid cysts without punctum may facilitate early diagnosis of Gorlin syndrome in children.

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Section: Discussionmentioning

confidence: 77%

Section: Discussionmentioning

confidence: 99%

Gorlin Syndrome: A Comprehensive Evaluation of Skin Findings

Atcı,

Melnicova,

Baykal

2024

Turkish Archives of Pediatrics

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“…A few acrochordons can also be the initial stage of basal cell carcinoma. 11 Microscopic evidence of fibro collagenous stroma with spindle cells or stellate cells at the epithelial-stromal interface is confirmatory. An expert pathological interpretation is required to differentiate acrochordons from angiomyofibroblastoma, aggressive angiomyxoma, cellular angiofibroma, and superficial angiomyxoma.…”

Section: Discussionmentioning

confidence: 87%

Large Vulval Acrochordon in Postmenopausal Woman—An Uncommon Presentation: Case Report

Mulik,

Acharya

2023

Journal of South Asian Federation of Obstetrics and Gynaecology

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Aim: To highlight the uncommon manifestation of acrochordon in a postmenopausal woman. Background: Acrochordons are benign mesenchymal neoplasms. They are frequently noted in women of reproductive age group. Their occurrence in postmenopausal women is rare. Case description: A 56-year-old multiparous postmenopausal woman presented with a large vulval acrochordon of size 8 cm × 7.5 cm × 7.5 cm. Total surgical excision was performed under regional anesthesia and its diagnosis was confirmed on histopathology. Conclusion: Vulvar acrochordons are uncommon. Their occurrence in a postmenopausal age group is rare. Complete surgical excision is the cure. Clinical significance: Their clinical features mimic malignancy hence histopathology is important for definitive diagnosis. Ultrasonography aids in the initial diagnosis of the lesion.

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“…Aunque el PFE es generalmente considerado una tumoración benigna y asintomática, se han comunicado casos aislados cuyo diagnóstico final fue carcinoma de células basales o carcinoma escamoso celular in situ, resaltando el rol de la histopatología en situaciones desafiantes (12) . En nuestros casos, el diagnóstico definitivo fue confirmado en base a examinación histopatológica, y ninguno de los especímenes evidenció células malignas.…”

Section: Reporte De Casosunclassified

Pólipo fibroepitelial vulvar: una serie de casos

Hernández Martínez,

Hernández Alarcón,

Fernández Silvestre

2023

Rev peru ginecol obstet.

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Los pólipos fibroepiteliales son tumores cutáneos benignos frecuentes en la poblacióngeneral. Sin embargo, la afectación del tracto genital es inhabitual. Su etiología no esclara, pero se han descrito asociaciones con trastornos metabólicos y fluctuacioneshormonales, lo cual explica su mayor prevalencia en mujeres. Debido a la variedad dediagnósticos diferenciales, es necesaria la evaluación histopatológica. Su manejo eshabitualmente conservador; sin embargo, pueden requerir intervención quirúrgicaen algunos casos. Exponemos cuatro casos de tumores fibroepiteliales vulvares dediferentes tamaños, uno de ellos clasificado como gigante, así como la aproximaciónde manejo. Con esta presentación, esperamos mejorar el conocimiento, la precisióndel diagnóstico y contribuir al tratamiento eficaz de las pacientes con esta patologíavulvar tan poco frecuente.

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Acrochordon-like basal cell carcinomas in patients with basal cell nevus syndrome

Cited by 15 publications

References 0 publications

Gorlin Syndrome: A Comprehensive Evaluation of Skin Findings

Gorlin Syndrome: A Comprehensive Evaluation of Skin Findings

Large Vulval Acrochordon in Postmenopausal Woman—An Uncommon Presentation: Case Report

Pólipo fibroepitelial vulvar: una serie de casos

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