2018
DOI: 10.1177/0956462417750709
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Acroangiodermatitis mimicking Kaposi’s sarcoma in an HIV-positive man

Abstract: Kaposi's sarcoma (KS) is the commonest human immunodeficiency virus (HIV)-related malignancy with its characteristic cutaneous morphological appearance and histopathological features. However, it can be simulated by other co-morbid opportunistic infections and unrelated dermatological conditions. We describe such a case of acroangiodermatitis in an HIV co-infected man, based on exclusion of KS histologically and the absence of human herpesvirus 8, the causative agent of KS.

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Cited by 4 publications
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“…Immunopathology can also be used to distinguish between PKS and KS. 10 CD34 expression is positive in both endothelial cells and surrounding mesenchyme in all stages of KS, whereas in PKS, CD34 expression is only positive in the vascular endothelium and negative in the vascular mesenchyme. 10 Additionally, human herpesvirus 8 (HHV-8) can help identify these two diseases.…”
Section: Discussionmentioning
confidence: 90%
See 1 more Smart Citation
“…Immunopathology can also be used to distinguish between PKS and KS. 10 CD34 expression is positive in both endothelial cells and surrounding mesenchyme in all stages of KS, whereas in PKS, CD34 expression is only positive in the vascular endothelium and negative in the vascular mesenchyme. 10 Additionally, human herpesvirus 8 (HHV-8) can help identify these two diseases.…”
Section: Discussionmentioning
confidence: 90%
“…10 CD34 expression is positive in both endothelial cells and surrounding mesenchyme in all stages of KS, whereas in PKS, CD34 expression is only positive in the vascular endothelium and negative in the vascular mesenchyme. 10 Additionally, human herpesvirus 8 (HHV-8) can help identify these two diseases. 11 KS is closely associated with HHV-8 infection, and all subtypes are associated with it, whereas the association between HHV-8 and PKS is less clear.…”
Section: Discussionmentioning
confidence: 99%
“…A differential diagnosis should be made to differentiate AAD from other conditions, such as Kaposi's sarcoma, vasculitis, actinic keratosis, stasis dermatitis, hemangiomas, lymphangiomas, and lymphangiosarcomas (7,8). It must be remarked that, in rare cases, AAD develops in patients presenting no CVI or any underlying AVMs (7,(9)(10)(11).…”
Section: Discussionmentioning
confidence: 99%