ACRIN 6691 monitoring and predicting breast cancer neoadjuvant chemotherapy response using diffuse optical spectroscopic imaging (DOSI).

Tromberg, BJ; Butler, Janet; Mankoff, David A.; Isakoff, SJ; Hylton, N.; Yodh, Arjun G.; Boas, David A.; Paulsen, Kristi J; Pogue, Brian W.; Kaufman, Paul; Mehta, Rita S.; Carpenter, Philip M.; Cerussi, AE; Zhang, Z.; Hartfeil, Donna; L'Heureux, DZ

doi:10.1200/jco.2011.29.15_suppl.tps249

Cited by 2 publications

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“…34 A multicentre clinical trial on the efficacy of NIR monitoring of neoadjuvant chemotherapy is currently recruiting patient-volunteers. 137 In the phase I/II multicentre study at five clinical sites, women who have been diagnosed with breast cancer, who have had confirmation of disease by pre-treatment biopsy and are scheduled to receive neoadjuvant chemotherapy followed by surgery are eligible for the trial.…”

Section: Discussionmentioning

confidence: 99%

A Review of Mechanisms of Contrast for Diffuse Optical Imaging of Cancer

Enfield

Gibson

2012

Journal of Near Infrared Spectroscopy

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This is a review not of the biology of cancer as a whole, but of the biological changes that occur within cells and tissue when cancer develops that can provide contrast for near infrared (NIR) spectroscopy and imaging methods. By understanding the biology, we should be able to explain and interpret our results with greater confidence. As NIR techniques for cancer detection and measurement are an extremely broad area for discussion, we concentrate on diffuse optical methods: diffuse optical imaging, NIR spectroscopy and selected methods such as photoacoustic imaging. We do not specifically include the microscopies or optical coherence tomography, although some of the points we make are relevant to these other methods. Diffuse optical spectroscopy and imaging will be referred to as DOSI throughout this review. What is cancer? Cancer is the collective term for a class of diseases in which a group of cells display uncontrolled growth, invade and destroy adjacent tissues and sometimes spread (metastasise) to other locations in the body via either the lymphatic system or the blood circulation. 1-3

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Section: Discussionmentioning

confidence: 99%

A Review of Mechanisms of Contrast for Diffuse Optical Imaging of Cancer

Enfield

Gibson

2012

Journal of Near Infrared Spectroscopy

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“…Currently, no standardized modalities and timing for the assessment of an early pathologic response have been established. Optical techniques are showing good promise for monitoring the effectiveness of neoadjuvant chemotherapy and even predicting the therapeutic response [8][9][10] . Actually, it seems possible to predict the outcome of the neoadjuvant chemotherapy just after the first day of treatment, or even before the start, based on characteristic features of breast tissue that provide indication on its responsiveness to treatment [11][12][13] .…”

Section: Introduction To Time-resolved Diffuse Optical Spectroscopymentioning

confidence: 99%

Time domain diffuse optical spectroscopy:In vivoquantification of collagen in breast tissue

et al. 2015

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Time-resolved diffuse optical spectroscopy provides non-invasively the optical characterization of highly diffusive media, such as biological tissues. Light pulses are injected into the tissue and the effects of light propagation on re-emitted pulses are interpreted with the diffusion theory to assess simultaneously tissue absorption and reduced scattering coefficients. Performing spectral measurements, information on tissue composition and structure is derived applying the Beer law to the measured absorption and an empiric approximation to Mie theory to the reduced scattering.The absorption properties of collagen powder were preliminarily measured in the range of 600-1100 nm using a laboratory set-up for broadband time-resolved diffuse optical spectroscopy.Optical projection images were subsequently acquired in compressed breast geometry on 218 subjects, either healthy or bearing breast lesions, using a portable instrument for optical mammography that operates at 7 wavelengths selected in the range 635-1060 nm. For all subjects, tissue composition was estimated in terms of oxy-and deoxy-hemoglobin, water, lipids, and collagen. Information on tissue microscopic structure was also derived.Good correlation was obtained between mammographic breast density (a strong risk factor for breast cancer) and an optical index based on collagen content and scattering power (that accounts mostly for tissue collagen). Logistic regression applied to all optically derived parameters showed that subjects at high risk for developing breast cancer for their high breast density can effectively be identified based on collagen content and scattering parameters.Tissue composition assessed in breast lesions with a perturbative approach indicated that collagen and hemoglobin content are significantly higher in malignant lesions than in benign ones.

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ACRIN 6691 monitoring and predicting breast cancer neoadjuvant chemotherapy response using diffuse optical spectroscopic imaging (DOSI).

Cited by 2 publications

References 0 publications

A Review of Mechanisms of Contrast for Diffuse Optical Imaging of Cancer

A Review of Mechanisms of Contrast for Diffuse Optical Imaging of Cancer

Time domain diffuse optical spectroscopy:In vivoquantification of collagen in breast tissue

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