Acral pigmented Spitz nevus in a child with transepidermal migration of melanocytes: Dermoscopic and reflectance confocal microscopic features

Iriarte, Christopher; Rao, Babar; Haroon, Attiya; Kirkorian, A. Yasmine

doi:10.1111/pde.13385

Cited by 4 publications

(3 citation statements)

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“…2 Since RCM has a penetration depth of up to 200 μm, the thickness of the stratum corneum in acral skin is the main limit of examination at RCM of lesions localized in this area. 23,24 Moreover, hyperkeratosis and/or presence of ulceration are additional wellknown factors that may limit the effectiveness of RCM. 23,25 Indeed, the majority of the lesions included in our study was in non-acral sites.…”

Section: Discussionmentioning

confidence: 99%

“…It is interesting to note that all seven EPs examined by means of RCM in the literature were localized in non‐acral sites, 11–17 although the most common location of EP is on the palmar or plantar surface 2 . Since RCM has a penetration depth of up to 200 μm, the thickness of the stratum corneum in acral skin is the main limit of examination at RCM of lesions localized in this area 23,24 . Moreover, hyperkeratosis and/or presence of ulceration are additional well‐known factors that may limit the effectiveness of RCM 23,25 .…”

Section: Discussionmentioning

confidence: 99%

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The role of reflectance confocal microscopy in the diagnosis of eccrine poroma: A retrospective case–control study

Francesca

Mandel

Stanganelli

et al. 2022

Experimental Dermatology

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Eccrine poroma (EP) is a rare benign adnexal tumor that may mimic benign or malignant tumors and differential diagnosis may be difficult under clinical and dermoscopic examination. Reflectance confocal microscopy (RCM) examination may add important information to diagnosis and subsequent management of solitary lesions for which dermoscopy can be challenging. The aim of the present study was to investigate features of EP at RCM in order to detect the characteristics that might aid in the differential diagnosis of EP versus other solitary lesions (benign or malignant). Secondary objective was to correlate the resulting features with histopathological findings. This monocentric retrospective observational case–control study included all EPs registered with RCM between January 2007 and May 2018. Control cases were benign or malignant lesions similar in clinical appearance, morphology, and dermoscopic features to EPs. RCM evaluators were blinded to clinical‐dermoscopic images and to final histopathological diagnoses. Finally, RCM‐histopathological correlation was performed. A total of 11 EPs and 33 controls were included in the present study. Among RCM parameters, “cords without palisading,” “dark holes,” “prominent vascularization” and “abundant stroma” resulted positively associated with EP in univariate analysis. RCM features correspond to the histopathological diagnosis of EP in 97% of cases, as illustrated by the cluster analysis. An excellent correlation between diagnostic features of conventional histopathology and RCM was observed. RCM assists in the differential diagnosis of solitary lesions, allowing to reach a correct diagnosis of EP through the identification of its four characteristics.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The role of reflectance confocal microscopy in the diagnosis of eccrine poroma: A retrospective case–control study

Francesca

Mandel

Stanganelli

et al. 2022

Experimental Dermatology

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“…Zur Differenzialdiagnose des Nävus Spitz zählt auch das juvenile Xanthogranulom, das ebenso mit der KLM diagnostiziert werden kann, somit können auch weitere "falsche Freunde" ausgeschlossen werden [18]. Dennoch können in der KLM manchmal Spitz-Nävi auffälliger aussehen, als sie es sind, und so fokale atypische Zellen als maligne beurteilt werden, ähnlich wie im Fall des akralen pigmentierten Nävus, publiziert von Iriarte et al, der sich histologisch als benigne herausstellte [8]. bar sind [9].…”

Section: Dermatophytosenunclassified