Acral Melanoma — A Distinct Molecular and Clinical Subtype

Barra-Martínez, Rosalva; Herrera-González, Norma Estela; –Ramírez, F. Fernández; Torres, Lorraine

doi:10.5772/59093

Cited by 2 publications

(2 citation statements)

References 45 publications

(42 reference statements)

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“…However, the trauma theory remains contentious, as other studies have not found this correlation; for example, a retrospective study of 122 acral melanomas from the Mayo Clinic found no significant difference in the distribution of acral melanomas on weight‐bearing and non‐weight‐bearing regions (Costello, Pittelkow, & Mangold, 2017). Additionally, analyses of the incidence of ALM in African tribes did not find differences in incidence between groups who wore shoes or were barefoot, although sample sizes were limited (Barra‐Martínez, Herrera‐González, Fernández‐Ramírez, & Torres, 2015; Rippey, Rippey, & Giraud, 1975).…”

Section: Epidemiologymentioning

confidence: 99%

Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease

Basurto-Lozada

Molina-Aguilar

Castañeda-García

et al. 2020

Pigment Cell Melanoma Res

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Section: Epidemiologymentioning

confidence: 99%

Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease

Basurto-Lozada

Molina-Aguilar

Castañeda-García

et al. 2020

Pigment Cell Melanoma Res

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“…Acral melanoma is a subtype of skin cancer that occurs on acral skin, such as the palms, soles, and nails. Recent statistical analysis of some malignancies showed that AM is the most common cutaneous melanoma in some populations such as Asians and Africans (1). Histologically melanoma has been classified into three major subtypes: Superficial Spreading Melanoma (SSM), Nodular Melanoma (NM) and Acral Lentiginous melanoma (ALM) (2).…”

Section: Introductionmentioning

confidence: 99%

BRAF Mutation Analysis in Primary Acral Melanoma of 41 Cases from South of Iran

et al. 2021

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Scan to discover onlineBackground & Objective: Acral melanoma (AM) is a common type of cutaneous melanoma that occurs in the skin of the palms, soles, and nail beds. This malignancy, like other types of cancer, has different genetic alterations. To date, despite decades of research the roles of oncogenic BRAF mutations in the pathogenesis of AM has not been fully clarified. The present study was designed to identify V600E mutation in patients with AM from the south of Iran. Methods:The samples were collected from the pathology lab archive of Shiraz University of Medical Sciences (2015)(2016)(2017)(2018)(2019)(2020). A total of 41 patients with primary invasive AM underwent excisional biopsy or amputation were collected to evaluate BRAF V600E mutation using Polymerase Chain Reaction (PCR) and Sanger sequencing.Results: Total number of 41cases (21 male and 20 female) and age range of 34-87 years were enrolled. The histological subtypes were 24 acral lentiginous melanomas (ALM), 10 cases of nodular melanoma (NM), and 7 cases of superficial spreading melanoma (SSM). In our study, only one case (a 44-year-old male with nail bed AM and the histological subtype of acral lentigenous melanoma) showed BRAF-V600E mutation. Conclusion:These findings suggest that the population of our interest showed a very low prevalence of this mutation providing novel insights into the pathobiology of AM and its related treatment.

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Acral Melanoma — A Distinct Molecular and Clinical Subtype

Cited by 2 publications

References 45 publications

Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease

Acral lentiginous melanoma: Basic facts, biological characteristics and research perspectives of an understudied disease

BRAF Mutation Analysis in Primary Acral Melanoma of 41 Cases from South of Iran

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