Acral localized acquired cutis laxa as presenting sign of underlying systemic amyloidosis

Abstract

Acral localized acquired cutis laxa (ALACL) is a rare variant of acquired cutis laxa, and the clinical appearance is characterized by loose, redundant and wrinkled skin of the distal extremities. By definition, histopathology of affected tissue reveals sparse or fragmented elastic fibers. However, this can be difficult to assess on routine staining, and sometimes requires electron microscopy. The condition has been associated with

Cutaneous manifestations of monoclonal gammopathy

“…8 ). Some localized forms also exists, including distal extremity involvement associated with systemic amyloidosis or multiple myeloma [ 154 ]. Very few studies describe stabilization or amelioration of cutis laxa following treatment of the underlying monoclonal gammopathy.…”