Acral keratosis with eosinophilic dermal deposits: a distinctive clinicopatholgic entity or colloid milium redux?

Abstract

The etiologic significance of this condition is unknown. Potential sources of the material and a discussion of the differential diagnosis follow.

Acral keratosis with eosinophilic dermal deposits: A rare subtype of colloid milium

“…There are five subtypes of CM 1 . AKEDD is the least common form and has been described in a single case series of six patients 2 . Histopathology of AKEDD shows symmetrical papules with central epidermal effacement overlying well‐circumscribed amorphous, homogeneous eosinophilic material in the papillary dermis.…”

“…Acral keratosis with eosinophilic dermal deposits has been described only in a single case series, in which six patients presented with slowly progressive hyperkeratotic papules on the dorsal or ventral aspects of the fingers 2 . Histopathologic findings showed symmetrical papules with central epidermal effacement overlying well‐circumscribed amorphous, homogeneous eosinophilic material in the papillary dermis with minimal inflammation.…”

“…1 AKEDD is the least common form and has been described in a single case series of six patients. 2 ACM is the most common form, presenting as translucent yellow dome-shaped papules on sun-exposed areas, primarily the face, neck, ears, and dorsal hands. JCM presents similarly but before puberty.…”