Acral Hyperpigmentation Resulting from Hydroxyurea Therapy in Primary Myelofibrosis

Kaewdech, Apichat; Aiempanakit, Kumpol; Apinantriyo, Benjawan

doi:10.1007/s12288-018-0940-2

Cited by 4 publications

(2 citation statements)

References 2 publications

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“…Medications frequently reported with melanonychia are hydroxyurea, zidovudine, and psoralen. 1,9,10 For onycholysis, other medications are tetracyclines, psoralen, and nonsteroidal antiinflammatory drugs. 1 Retinoids, indinavir, methotrexate, capecitabine, sirolimus, and epidermal growth factor receptor inhibitors reported paronychia and pyogenic granuloma.…”

Section: Discussionmentioning

confidence: 99%

Beau’s Lines Resulting from Taxane Chemotherapy

Aiempanakit¹

2018

J Health Sci Med Res

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Nail abnormalities are frequently found in oncologic patients who have undergone chemotherapy. Although thesechanges do not require treatment, they could influence the treatment plan and the patient’s quality of life. Some naildisorders lead to severe complications. Herein, the author reports on a patient with advanced breast cancer who received multiple kinds and cycles of chemotherapy. She developed multiple, parallel, transverse grooves, compatible with Beau’s lines, on the nail plate of all her fingernails and toenails. This report aims to further the knowledge of medical students, physicians, and healthcare providers regarding the nails of patients who receive chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Beau’s Lines Resulting from Taxane Chemotherapy

Aiempanakit¹

2018

J Health Sci Med Res

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“…Other nail changes described in Kawasaki disease include transverse leukonychia, Beau's lines, onychomadesis, and pincer nails . Transverse orange‐brown chromonychia may also result particularly from chemotherapy, for example, with hydroxyurea …”

Section: Differential Diagnosismentioning

confidence: 99%

Melanonychia striata: clarifying behind the Black Curtain. A review on clinical evaluation and management of the 21st century

et al. 2019

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Melanonychia striata is characterized by a tan, brown, or black longitudinal streak within the nail plate that runs from the proximal nail fold to the distal part of the nail plate.Melanonychia striata is due to increased activity of melanocytes or melanocytic hyperplasia in the nail matrix with subsequently increased melanin deposition in the nail plate. The most common cause of melanonychia striata associated with melanocytic activation is ethnic melanonychia which occurs in dark-skinned individuals. Other causes of melanonychia striata related to melanocytic activation include pregnancy, chronic local trauma, infections, medications, dermatological disorders, endocrine disorders, alkaptonuria, hemochromatosis, porphyria, graft-vs-host disease, Peutz-Jeghers syndrome, and Laugier-Hunziker syndrome. Causes of melanonychia striata associated with melanocytic hyperplasia include nail matrix melanocytic nevus, nail lentigo, and nail apparatus/subungual in situ and invasive melanoma. In most cases, melanonychia striata is a benign condition, especially in children. Consequently, most investigators advocate a wait-and-see approach. Nail apparatus/subungual melanoma should be suspected if there is an abrupt onset after middle age, personal or family history of melanoma, rapid growth, darkening of a melanonychia band, pigment variegation, blurry lateral borders, irregular elevation of the surface, a bandwidth >3 mm, proximal widening, associated nail plate dystrophy, single rather than multiple digit involvement, and periungual spread of pigmentation onto the adjacent cuticle and/or proximal and/or lateral nail folds (Hutchinson sign). Prolonged follow-up is mandatory for early detection of possible malignant changes.

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Hydroxycarbamide

2018

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Acral Hyperpigmentation Resulting from Hydroxyurea Therapy in Primary Myelofibrosis

Cited by 4 publications

References 2 publications

Beau’s Lines Resulting from Taxane Chemotherapy

Beau’s Lines Resulting from Taxane Chemotherapy

Melanonychia striata: clarifying behind the Black Curtain. A review on clinical evaluation and management of the 21st century

Hydroxycarbamide

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