ACR Appropriateness Criteria ® Ovarian Cancer Screening

Imaging:, Expert Panel on Women’s; Pandharipande, Pari V.; Lowry, Kathryn P.; Reinhold, Caroline; Atri, Mostafa; Benson, Carol B.; Bhosale, Priyadarshani R.; Green, Edward D.; Kang, Stella K.; Lakhman, Yulia; Maturen, Katherine E.; Nicola, Refky; Salazar, Gloria M.; Shipp, Thomas; Simpson, Lynn L.; Sussman, Betsy L; Uyeda, Jennifer W.; Wall, Darci J.; Whitcomb, Bradford P.; Zelop, Carolyn M.; Glanc, Phyllis

doi:10.1016/j.jacr.2017.08.049

Cited by 11 publications

(8 citation statements)

References 36 publications

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“…The recommendation regarding transvaginal pelvic US performed with or without color Doppler US in these women is that this examination "may be appropriate." It should be noted that the ACR currently proposes that pelvic MRI with and without intravenous contrast material is "usually not appropriate" for screening (111). For endometrial cancer, the ACR appropriateness criteria indicate that transvaginal US is the preferred screening examination and can also be used to assess myometrial invasion.…”

Section: Discussionmentioning

confidence: 99%

BRCAand Beyond: Comprehensive Image-rich Review of Hereditary Breast and Gynecologic Cancer Syndromes

et al. 2020

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In addition to the well-characterized BRCA1 and BRCA2 hereditary breast and ovarian cancer syndromes, many other syndromes that are associated with genetic mutations predispose individuals to an increased risk of breast and gynecologic malignancies. Many mutated genes encode for tumor-suppressor products and are inherited in an autosomal dominant manner. Mutations markedly increase an individual's lifetime risk of cancers in different organ systems, depending on the associated syndrome. These syndromes include Lynch syndrome, the most common hereditary cause of endometrial cancer, and Peutz-Jeghers syndrome, which increases the risks of breast cancer, ovarian cancer, and cervical adenoma malignum. Li-Fraumeni syndrome and Cowden syndrome increase the risk of breast cancer, and Gorlin syndrome increases the risk of ovarian fibromas. With advances in genetic testing, clinicians' knowledge and awareness of the numerous additional genes associated with breast and ovarian cancers, such as ATM, CHEK2, and PALB2, are rapidly expanding. Radiologists have essential roles in patient management, which include developing optimal screening protocols for these patients and closely monitoring them for the development or recurrence of disease-specific malignancies. Radiologists' roles continue to increase and evolve as more mutations are identified and high-risk imaging screening recommendations expand to identify these patients. Understanding the epidemiologic, genetic, and pathophysiologic features and the cancers associated with these syndromes enables radiologists to appropriately contribute to patient management, ensure accurate and timely diagnosis, and make syndrome-specific imaging recommendations.© RSNA, 2020 • radiographics.rsna.org

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Section: Discussionmentioning

confidence: 99%

BRCAand Beyond: Comprehensive Image-rich Review of Hereditary Breast and Gynecologic Cancer Syndromes

et al. 2020

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“…Screening may even pose harm, with a substantial number of major surgical complications resulting from false-positive cases (16). Despite these risks, several organizations support offering screening transvaginal US to high-risk women (7,(10)(11)(12)(13)(14)(15). In some screening studies involving high-risk patients with a genetic or family history, a stage shift has been observed, with the diagnosis at earlier stages.…”

Section: Discussionmentioning

confidence: 99%

Radiologic-Histopathologic Correlation of Transvaginal US and Risk-reducing Salpingo-oophorectomy for Women at High Risk for Tubo-ovarian Carcinoma

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Masch

et al. 2020

Radiology: Imaging Cancer

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“…ACR does not recommend tomography without contrast administration. Sensitivity and specificity of CT in myometrium infiltration assessment ranges from 40 to 83% and respectively 42 to 75%, while accuracy in myometrium and cervix infiltration assessment is 81 to 95% [1,18].…”

Section: Endometrial Cancermentioning

confidence: 99%