ACR Appropriateness Criteria® on Solitary Pulmonary Nodule

Khan, Arfa

doi:10.1016/j.jacr.2006.12.003

Cited by 20 publications

(9 citation statements)

References 26 publications

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“…Nodules that were ≥ 5mm or calcified were more likely to be malignant. The correlation between malignancy and calcification is interesting, as it is the opposite of what is observed in the adult population, in which nodules with calcification are more likely to be benign (22). To get a homogeneous patient population we only included patients in our study whose primary tumors were osteosarcomas.…”

Section: Discussionmentioning

confidence: 95%

“…CT imaging characteristics of pulmonary nodules used for determining their nature in adults include nodule contour, margins and internal characteristics. However, only two characteristics are considered to be sufficiently predictive to preclude further evaluation in adult patients and classify the nodule as benign: calcification in a benign pattern and stability in size for > 2 years (22). …”

Section: Discussionmentioning

confidence: 99%

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Do characteristics of pulmonary nodules on computed tomography in children with known osteosarcoma help distinguish whether the nodules are malignant or benign?

Brader

Abramson

Price

et al. 2011

Journal of Pediatric Surgery

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Purpose To determine if selected computed tomography (CT) characteristics of pulmonary nodules in pediatric patients with osteosarcoma can help distinguish the nodules as benign or malignant. Methods The institutional review board approved this HIPAA-compliant, retrospective study of 30 pediatric osteosarcoma patients (median age 14 years, range 8-22) who underwent chest CT with resection of 117 pulmonary nodules from January 2001 to December 2006. Two pediatric radiologists and one chest radiologist independently and retrospectively reviewed the CT scans and classified nodules as benign, malignant, or indeterminate on the basis of nodule size, laterality, number, location, growth, density, margin appearance and calcification. Generalized estimating equations were used to examine which characteristics were independent predictors of nodule malignancy. Results Of the 117 nodules, 80 (68%) were malignant and 37 (32%) were benign by pathologic review. The readers correctly classified 93-94% of the malignant nodules. For benign lesions, the results were not as accurate, with the readers correctly classifying only 11-30% of lesions. The majority of benign lesions were classified as indeterminate by the readers (54-65%). Nodule size (≥ 5 mm) and the presence of calcifications were associated with an increased probability of malignancy (p<0.05). Conclusion On chest CT, nodule size ≥ 5 mm and the presence of calcifications are associated with an increased probability of malignant nodule histology in pediatric patients with osteosarcoma. However, nodule characteristics, apart from size and calcification, at chest CT cannot reliably distinguish benign from malignant pulmonary nodules in these patients.

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Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Do characteristics of pulmonary nodules on computed tomography in children with known osteosarcoma help distinguish whether the nodules are malignant or benign?

Brader

Abramson

Price

et al. 2011

Journal of Pediatric Surgery

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“…Although this review will especially focus on sub-centimeter lesions, comparisons with larger SPNs will be made. Reviews on the further work-up and treatment of potential malignant nodules can be found elsewhere [6,[19][20][21][22][23][24][25].…”

Section: Figmentioning

confidence: 99%

How to deal with incidentally detected pulmonary nodules less than 10mm in size on CT in a healthy person

Westeinde

Koning

et al. 2008

Lung Cancer

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“…Our results showed that, the case number of calcification within benign SPN lesions is significantly higher than the malignant lesions. In the past, calcification has once been recognized as benign lesion ( 17 ). However, later studies have shown that, even SPN cases with calcification could not be excluded from malignant tumors ( 18 ).…”

Section: Discussionmentioning

confidence: 99%

Differential diagnostic value of 64‑slice spiral computed tomography in solitary pulmonary nodule

Wang

Zheng

et al. 2018

Exp Ther Med

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The present study aimed to evaluate the diagnostic value of 64-slice spiral multivariate computed tomography (CT) combined with dynamic contrast-enhanced scanning for benign and malignant solitary pulmonary nodules (SPNs). A total of 93 patients with SPN as diagnosed by CT were included. All these patients were subjected to routine and dynamic enhancement CT scanning. After reconstruction, the morphological characteristics following dynamic enhancement were analyzed, and compared for the benign and malignant SPN cases. The incidences of lobulation, spicular sign, pleural indentation and vacuole sign in the malignant SPN group were significantly higher compared with the benign SPN group. During the dynamic enhancement scanning, the CT values at all the time points for the inflammatory and malignant SPN groups were significantly higher than the benign SPN group. No significant differences were observed in the dynamic enhancement CT values at 30, 60, 90 and 120 sec between the inflammatory, and malignant SPN groups. However, in the inflammatory SPN group, the dynamic enhancement CT values at 300 and 540 sec were significantly lower than the malignant SPN group. Notably, the diagnostic accordance rate for the morphological signs combined with dynamic enhancement diagnosis was significantly higher than the morphological signs alone. The 64-slice spiral CT morphological signs combined with dynamic enhancement detection can be more effective for the differential diagnosis of benign and malignant SPN, which may provide potent evidence for the early clinical treatment.

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ACR Appropriateness Criteria® on Solitary Pulmonary Nodule

Cited by 20 publications

References 26 publications

Do characteristics of pulmonary nodules on computed tomography in children with known osteosarcoma help distinguish whether the nodules are malignant or benign?

Do characteristics of pulmonary nodules on computed tomography in children with known osteosarcoma help distinguish whether the nodules are malignant or benign?

How to deal with incidentally detected pulmonary nodules less than 10mm in size on CT in a healthy person

Differential diagnostic value of 64‑slice spiral computed tomography in solitary pulmonary nodule

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