Acquisition of Mycoplasmata and T-Strains during Infancy

Foy, Hjordis M.; Kenny, George E.; Levinsohn, E. Mark; Grayston, J. T.

doi:10.1093/infdis/121.6.579

Cited by 49 publications

(12 citation statements)

References 16 publications

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“…Interest in the epidemiology of genital mycoplasma infections in infants began more than 30 years ago, when the association was made that colonization of newborn infants was inversely related to birth weight (35,86,147 (316). First, there can be an ascending intrauterine infection in which the organisms gain access to the amniotic sac, where they multiply and are then passed into the fetal lung.…”

Section: Vertical Transmissionmentioning

confidence: 99%

“…Although the presence of Ureaplasma spp. has been documented for long periods in the lower respiratory tract of preterm infants (45), surface colonization of full-term infants tends to be transient and declines beyond 3 months of age (86). Recolonization of the lower urogenital tract may occur following puberty and when sexual activity is initiated, or if there is sexual abuse (313).…”

Section: Vertical Transmissionmentioning

confidence: 99%

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Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Katz²,

2005

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SUMMARY The genital mycoplasmas represent a complex and unique group of microorganisms that have been associated with a wide array of infectious diseases in adults and infants. The lack of conclusive knowledge regarding the pathogenic potential of Mycoplasma and Ureaplasma spp. in many conditions is due to a general unfamiliarity of physicians and microbiology laboratories with their fastidious growth requirements, leading to difficulty in their detection; their high prevalence in healthy persons; the poor design of research studies attempting to base association with disease on the mere presence of the organisms in the lower urogenital tract; the failure to consider multifactorial aspects of diseases; and considering these genital mycoplasmas only as a last resort. The situation is now changing because of a greater appreciation of the genital mycoplasmas as perinatal pathogens and improvements in laboratory detection, particularly with regard to the development of powerful molecular nucleic acid amplification tests. This review summarizes the epidemiology of genital mycoplasmas as causes of neonatal infections and premature birth; evidence linking ureaplasmas with bronchopulmonary dysplasia; recent changes in the taxonomy of the genus Ureaplasma; the neonatal host response to mycoplasma and ureaplasma infections; advances in laboratory detection, including molecular methods; and therapeutic considerations for treatment of systemic diseases.

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Section: Vertical Transmissionmentioning

confidence: 99%

Section: Vertical Transmissionmentioning

confidence: 99%

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Katz²,

2005

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“…Colonization of healthy full-term infants is relatively transient, with a sharp drop in isolation rates after 3 months of age (39,60). Long-term follow-up studies with premature infants have not been conducted.…”

Section: Colonization Of the Lower Genital Tractmentioning

confidence: 99%

Ureaplasma urealyticum intrauterine infection: role in prematurity and disease in newborns

et al. 1993

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Ureaplasma urealyticum, a common commensal of the urogenital tract of sexually mature humans, is gaining recognition as an important opportunistic pathogen during pregnancy. While its etiologic significance in many aspects of adverse pregnancy remains controversial, recent evidence indicates that U. urealyticum in the absence of other organisms is a cause of chorioamnionitis. Furthermore, ureaplasmal infection of the chorioamnion is significantly associated with premature spontaneous labor and delivery. In at least some cases, it appears to be causal. Present evidence indicates that U. urealyticum is a cause of septicemia, meningitis, and pneumonia in newborn infants, particularly those born prematurely. There is strong but not definitive evidence that ureaplasmal infection of the lower respiratory tract can lead to development of chronic lung disease in very low-birth-weight infants. Although risk factors for colonization of the lower genitourinary tract have been identified, little information is available concerning risk factors for intrauterine infection and host immune responses to invasive infection. Recent establishment of animal models of respiratory and central nervous system diseases should provide an opportunity to evaluate risk factors, pathogenic mechanisms, and operative immune mechanisms. However, the most critical need is additional information concerning indications for diagnosis and treatment as well as efficacy of treatment.

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“…Cependant, cette colonisation bactérienne néonatale semble être transitoire la plupart du temps. Après trois mois, on observe une nette diminution de la prévalence des mycoplasmes génitaux (taux inférieurs à 10 % jusqu'à la puberté et le début de l'activité sexuelle) [36,37].…”

Section: Infections Néonatalesunclassified

Mycoplasmes génitaux

Judlin¹

2003

Gynécologie Obstétrique & Fertilité

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Acquisition of Mycoplasmata and T-Strains during Infancy

Cited by 49 publications

References 16 publications

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Mycoplasmas and Ureaplasmas as Neonatal Pathogens

Ureaplasma urealyticum intrauterine infection: role in prematurity and disease in newborns

Mycoplasmes génitaux

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