Based on selected research studies that are among the most highly-cited or considered seminal or influential, this chapter provides an overview of the various qualitative, quantitative, and mixedmethods approaches that have been used to date in CALL research. CALL is used to refer to "Computer-Assisted Languaculture Learning," which encompasses not just second language learning but also learning about the cultures associated with these languages. Areas of investigation have included learning of grammar, vocabulary, reading/writing, listening/speaking, pragmatics and intercultural competence, as well as overall communicative and intercultural competence. Technologies investigated in these areas range from tutorial lessons to collaborative Internet-based projects. Potential future methodologies and directions for future research are discussed for Computer-Assisted Languaculture Learning. There are various ways that this chapter could be organized. One could categorize studies into quantitative, qualitative, or mixed methods and discuss how these different methods have been used in the seminal studies. One could examine the different aspects of languaculture (e.g., speaking, reading, grammar, vocabulary, culture, identity), how they have been taught, learned,