Acquisition and reconditioning of ethanol-induced conditioned place preference in mice is blocked by the H2O2 scavenger alpha lipoic acid

Abstract

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Genetic and Environmental Predictors of Alcohol Use in Asian American Young Adults

“…Of note, significant debate exists about the ubiquity of acetaldehyde's aversiveness, with some studies suggesting that brain-derived acetaldehyde may actually partially mediate alcohol's rewarding effects (Israel et al, 2013;Ledesma & Aragon, 2013;Rodd et al, 2005), whereas peripheral acetaldehyde causes the aversive physiological effects (Israel et al, 2013;Mizoi et al, 1983;Shimoda et al, 1996). Although speculative at this point and in need of direct empirical examination in future studies with large samples, the results of this study are consistent with the possibility that brain acetaldehyde may actually be reinforcing.…”

Mystic Acetaldehyde: The Never-Ending Story on Alcoholism

“…These studies showed that local intra-arcuate nucleus of the hypothalamus administration of another catalase inhibitor, sodium azide, could prevent the locomotor stimulating properties of ethanol (Sanchis-Segura et al, 2005) and that the systemic administration of catalase inhibitors could prevent both the locomotor stimulant effects of intra-substantia nigra pars reticulata (SNr) administration of ethanol (Arizzi-LaFrance et al, 2006) and the anxiolytic effects of systemically-administered ethanol (Correa et al, 2008). Further recent evidence on the role of catalase-mediated metabolism of ethanol was provided by the studies on ethanol-elicited locomotor stimulation, CPP (Ledesma and Aragon, 2012; Ledesma et al, 2012, 2013) and acquisition of ethanol oral self-administration (Peana et al, 2015). In summary, although acetaldehyde is generated locally in pharmacologically-significant amounts (Deng and Deitrich, 2008) by brain catalase, this process seems circumscribed to some specific brain nuclei (such as hypothalamus and midbrain) providing anatomical validation to the high behavioral specificity of the effects of drugs able to interfere with its enzymatic activity (Smith et al, 1997; Sanchis-Segura et al, 2005; Arizzi-LaFrance et al, 2006).…”

Elucidating the biological basis for the reinforcing actions of alcohol in the mesolimbic dopamine system: the role of active metabolites of alcohol

“…The hydrogen peroxide (H 2 O 2 ) scavenging compounds ebselen and alpha lipoic acid inhibit the formation of ACD through their reduction in the catalase-H 2 O 2 reaction and subsequent formation of Compound I (Cohen et al, 1980). Ledesma and colleagues have demonstrated that exposure to both ebselen or alpha lipoic acid inhibit EtOH-stimulated locomotor activity in mice (Ledesma et al, 2012; Ledesma and Aragon, 2013). …”