Acquisition and quantitation in proton spectroscopy

Abstract

Localized proton NMR spectroscopy in the human brain is one of the more technically advanced applications of human in vivo NMR spectroscopy. Spin/echo techniques introduced reliable localization procedures, whereas the introduction of phase encoding techniques improved the spatial information content considerably. Using the sensitivity of the 1H NMR signal, a spatial resolution of 7 X 7 X 15 mm can be obtained. Chemical shift images can be reconstructed to represent the choline, creatine, N-acetyl aspartate and lactate distribution in the human brain. These low resolution images may be used as a new functional imaging modality to visualize and derive quantitative biochemical information from focal brain lesions under normal and pathological conditions.

Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: Assessment of the load of disease

“…Water-suppressed, localized proton spectra were obtained using a Philips Gyroscan 1.5 T combined imaging and spectroscopy system (2). Multislice images were obtained in three planes.…”

Proton Magnetic Resonance Spectroscopy in Dementia of Alzheimer Type

“…Myo-inositol is a precursor of second messengers and a constituent of membrane lipids (Kofmann et al, 1991;Miller 1991;Ross, 1991). The highest peak of the proton spectrum usually results from NAA (Barany et al, 1987;Frahm et al, 1989;Luyten et al, 1991); NAA is found in high amounts in the brain, but not in other tissue (1/1000 of brain weight). It was observed in neurons and oligodendrocytes (Urenjak et al, 1992(Urenjak et al, , 1993.…”

Detection of metabolic heterogeneity of human intracranial tumors in vivo by 1h nmr spectroscopic imaging

“…"Single shot" volume selection for localized single volume 'H NMR spectroscopy was achieved with a stimulated echo RF pulse sequence (21,(35)(36)(37)(38), whereby two out of the three 90" RF pulses were spatially selective in two orthogonal directions. Volume selection in the third direction was achieved by refocusing the stimulated echo by a 180" RF pulse which was spatially selective in that direction.…”