Acquisition and expression of fat-conditioned flavor preferences are differentially affected by NMDA receptor antagonism in BALB/c and SWR mice

Kraft, Tamar T.; Huang, Donald; LaMagna, Sam; Warshaw, Deena; Natanova, Elona; Sclafani, Anthony; Bodnar, Richard J.

doi:10.1016/j.ejphar.2017.01.034

Cited by 6 publications

(3 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Interestingly, mesolimbic dopamine can be highly sensitive to the precise caloric content of nutrients. Fat, similar to sucrose and glucose, also elicits post-ingestive feedback mechanisms that influence goal-directed behaviors ( 171 , 173 – 175 ). When fat is delivered intragastrically, dorsal striatal dopamine levels increase in parallel with increasing caloric density of fat infusions, and dopamine receptor blockade impairs an animal's ability to regulate caloric intake ( 176 ).…”

Section: Homeostatic Signals Are Relayed To Mesolimbic Pathwaysmentioning

confidence: 99%

Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons

2018

View full text Add to dashboard Cite

Motivated behaviors are often initiated in response to perturbations of homeostasis. Indeed, animals and humans have fundamental drives to procure (appetitive behaviors) and eventually ingest (consummatory behaviors) substances based on deficits in body fluid (e.g., thirst) and energy balance (e.g., hunger). Consumption, in turn, reinforces motivated behavior and is therefore considered rewarding. Over the years, the constructs of homeostatic (within the purview of the hypothalamus) and reward (within the purview of mesolimbic circuitry) have been used to describe need-based vs. need-free consumption. However, many experiments have demonstrated that mesolimbic circuits and “higher-order” brain regions are also profoundly influenced by changes to physiological state, which in turn generate behaviors that are poised to maintain homeostasis. Mesolimbic pathways, particularly dopamine neurons of the ventral tegmental area (VTA) and their projections to nucleus accumbens (NAc), can be robustly modulated by a variety of energy balance signals, including post-ingestive feedback relaying nutrient content and hormonal signals reflecting hunger and satiety. Moreover, physiological states can also impact VTA-NAc responses to non-nutritive rewards, such as drugs of abuse. Coupled with recent evidence showing hypothalamic structures are modulated in anticipation of replenished need, classic boundaries between circuits that convey perturbations in homeostasis and those that drive motivated behavior are being questioned. In the current review, we examine data that have revealed the importance of mesolimbic dopamine neurons and their downstream pathways as a dynamic neurobiological mechanism that provides an interface between physiological state, perturbations to homeostasis, and reward-seeking behaviors.

show abstract

Section: Homeostatic Signals Are Relayed To Mesolimbic Pathwaysmentioning

confidence: 99%

Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons

2018

View full text Add to dashboard Cite

show abstract

“…Mice that received systemic MK-801, an NMDA receptor antagonist, demonstrated blunted fat preference. Kraft et al ( 105 ) confirmed these findings in Balb/c and SWR mice. Kraft et al also found that MK-801 eliminated preference for an intralipid-flavored solution.…”

Section: Discussionmentioning

confidence: 72%

“…However, the role of NMDA receptors in fat perception and their mechanisms are not fully understood. In this review, three studies examined the role of glutamatergic signaling in fat perception ( 91 , 105 , 120 ).…”

Section: Discussionmentioning

confidence: 99%

A systematic review of the biological mediators of fat taste and smell

Jaime-Lara

Brooks

Vizioli

et al. 2023

Physiological Reviews

View full text Add to dashboard Cite

Taste and smell play a key role in our ability to perceive foods. Overconsumption of highly palatable energy-dense foods can lead to increased caloric intake and obesity. Thus there is growing interest in the study of the biological mediators of fat taste and associated olfaction as potential targets for pharmacologic and nutritional interventions in the context of obesity and health. The number of studies examining mechanisms underlying fat taste and smell has grown rapidly in the last 5 years. Therefore, the purpose of this systematic review is to summarize emerging evidence examining the biological mechanisms of fat taste and smell. A literature search was conducted of studies published in English between 2014 and 2021 in adult humans and animal models. Database searches were conducted using PubMed, EMBASE, Scopus, and Web of Science for key terms including fat/lipid, taste, and olfaction. Initially, 4,062 articles were identified through database searches, and a total of 84 relevant articles met inclusion and exclusion criteria and are included in this review. Existing literature suggests that there are several proteins integral to fat chemosensation, including cluster of differentiation 36 (CD36) and G protein-coupled receptor 120 (GPR120). This systematic review will discuss these proteins and the signal transduction pathways involved in fat detection. We also review neural circuits, key brain regions, ingestive cues, postingestive signals, and genetic polymorphism that play a role in fat perception and consumption. Finally, we discuss the role of fat taste and smell in the context of eating behavior and obesity.

show abstract

Conditioned flavor preferences in animals: Merging pharmacology, brain sites and genetic variance

Bodnar

2018

Appetite

View full text Add to dashboard Cite

Acquisition and expression of fat-conditioned flavor preferences are differentially affected by NMDA receptor antagonism in BALB/c and SWR mice

Cited by 6 publications

References 54 publications

Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons

Parallels and Overlap: The Integration of Homeostatic Signals by Mesolimbic Dopamine Neurons

A systematic review of the biological mediators of fat taste and smell

Conditioned flavor preferences in animals: Merging pharmacology, brain sites and genetic variance

Contact Info

Product

Resources

About