Abstract:We report a 62-year-old woman with acquired tufted angioma. Several scattered reddish nodules were present on the neck and upper chest. During a follow-up period of 6 months, some of the lesions showed transient spontaneous regression and one disappeared completely. Electron microscopy revealed that a few tumour cells contained Weibel-Palade bodies in their cytoplasm.
“…Only 19 cases have been reported to have the first lesions after the age of 50 years as in the present case [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15]. The oldest age at onset was 84 [15].…”
Section: Discussionmentioning
confidence: 95%
“…Twenty-three cases were reported to reveal the tendency of spontaneous regression [5, 6, 20, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34]. In 18 cases out of the 23, the lesions developed within the first 6 months of life.…”
Section: Discussionmentioning
confidence: 99%
“…To date, only Miyamoto et al [6]and Lam et al [25]have described the histological features of regression in their lesions. The former observed that the collagen fibers penetrated the tumor lobules and suggested that the collagen fibers replaced the tumor tissues in the stage of spontaneous regression.…”
Section: Discussionmentioning
confidence: 99%
“…In 18 cases out of the 23, the lesions developed within the first 6 months of life. Only 1 adult-onset case has been reported, showing spontaneous regression [6], except for 2 cases having the lesions temporarily during pregnancy [24]or after liver transplantation [5]. …”
Tufted angioma (angioblastoma) usually occurs in infancy. Some lesions reveal proliferation of eccrine glands and some undergo spontaneous regression. We report a lesion from the left lateral chest of a 58-year-old male, which had appeared 5 years ago and gradually increased in size. Its color had faded out centrally. Histological examination showed many angiomatous lobules on the border of the lesion but few in the central portion. Abundant eccrine sweat glands, small venules and dense connective tissue were seen in both areas. The histology and the clinical course suggested that central regression occurred in the lesion. Out of 211 reported cases, we found 4 cases that had annular lesions spreading centrifugally. Though these lesions were not examined histologically, they were suspected to regress in the central portions. We suggest that central regression can rarely occur in tufted angioma.
“…Only 19 cases have been reported to have the first lesions after the age of 50 years as in the present case [3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15]. The oldest age at onset was 84 [15].…”
Section: Discussionmentioning
confidence: 95%
“…Twenty-three cases were reported to reveal the tendency of spontaneous regression [5, 6, 20, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34]. In 18 cases out of the 23, the lesions developed within the first 6 months of life.…”
Section: Discussionmentioning
confidence: 99%
“…To date, only Miyamoto et al [6]and Lam et al [25]have described the histological features of regression in their lesions. The former observed that the collagen fibers penetrated the tumor lobules and suggested that the collagen fibers replaced the tumor tissues in the stage of spontaneous regression.…”
Section: Discussionmentioning
confidence: 99%
“…In 18 cases out of the 23, the lesions developed within the first 6 months of life. Only 1 adult-onset case has been reported, showing spontaneous regression [6], except for 2 cases having the lesions temporarily during pregnancy [24]or after liver transplantation [5]. …”
Tufted angioma (angioblastoma) usually occurs in infancy. Some lesions reveal proliferation of eccrine glands and some undergo spontaneous regression. We report a lesion from the left lateral chest of a 58-year-old male, which had appeared 5 years ago and gradually increased in size. Its color had faded out centrally. Histological examination showed many angiomatous lobules on the border of the lesion but few in the central portion. Abundant eccrine sweat glands, small venules and dense connective tissue were seen in both areas. The histology and the clinical course suggested that central regression occurred in the lesion. Out of 211 reported cases, we found 4 cases that had annular lesions spreading centrifugally. Though these lesions were not examined histologically, they were suspected to regress in the central portions. We suggest that central regression can rarely occur in tufted angioma.
“…149 The lesions form and grow slowly and then remain stable in size; in some cases, regression has been reported. 150,151 Although tufted angiomas are usually sporadic, 2 families have been reported in which the lesions segregate in a dominant manner with low penetrance. 149,152 Lymphedema Lymphatic vessels play a central role in maintaining interstitial fluid balance.…”
Abstract-Increased understanding of the mechanisms of angiogenesis and lymphangiogenesis has provided a glimpse at some of the molecules involved in the pathophysiology of hemangiomas and vascular malformations. This review focuses on recent advances in our understanding of the mechanisms of angiogenesis/lymphangiogenesis and the differentiation of arterial, venous, and lymphatic vessels. We integrate this knowledge with new data obtained from genetic studies in humans, which have revealed a number of heretofore-unsuspected candidates involved in the development of familial vascular anomalies. We present a common infantile vascular tumor, hemangioma, and then focus on hereditary familial vascular and lymphatic malformations. We also summarize transgenic mouse models for some of these malformations. It seems reasonable to believe that novel therapeutic strategies will soon emerge for the treatment of hemangiomas and vascular malformations.
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