Acquired Tufted Angioma of Upper Lip: Case Report and Review of the Literature

Abstract

Acquired tufted angioma is a rare, cutaneous and slow growing benign vascular neoplasm that usually affects pediatric populations. Only six cases of oral mucosal acquired tufted angioma have been reported in the English language literature. We present in this report the seventh case and discuss its clinical and pathological features.

Childhood Vascular Tumors

“…Tufted angiomas are classified as benign vascular tumors by the ISSVA, but it is pertinent to distinguish them from infantile and congenital hemangiomas, as they may be complicated by Kasabach-Merritt Phenomenon. Tufted angiomas typically appear within the first 5 years of life and may be present at birth, though sporadic cases of acquired tufted angiomas in adult patients have been reported (28,29). They are slow-growing, erythematous to violaceous indurated plaques on the neck or upper trunk, often poorly-demarcated.…”

Tufted Angioma in Children: Report of Two Cases and a Review of the Literature

“…They may grow rapidly and their color ranges from red-brown to purple-blue. Most of cases are localized in lip [ 1 , 10 , 11 ]. The characteristics observed in the present reported cases are similar to previous reports, in which the lesion observed is characterized as a firm, red to purple nodule.…”

“…Clinical differential diagnosis of the tufted angioma in lip should include reactive lesions, such as pyogenic granuloma and mucocele and benign neoplasms from endothelial or salivary gland origin. However, the histopathological findings are specific and these lesions exhibit individual characteristics by which they can be distinguished from TA [ 10 ].…”

“…Its localization is typically on the skin of the neck, thorax, shoulders, and extremities [ 1 , 2 , 7 , 9 ], and it commonly affects children and young adults [ 1 , 3 ]. Mucosa involvement is rare [ 1 , 10 ]; the first case affecting oral mucosa was described by Kleinegger et al in 2000 [ 11 ].…”

73 Management of Vascular Anomalies: Hemangiomas and Malformations

“…24 These lesions demonstrate tightly packed capillaries of vascular tufts distributed in a "cannonball" pattern surrounded by slit-like vascular spaces and stroma. 53 KHE presents either at birth or shortly thereafter and has a similar appearance to TA with a bruise-like plaque that thickens and becomes more mass-like and nodular. These lesions are more deeply infiltrative than TA or IH, may grow rapidly, and some regress within the first 2 years of life.…”