Acquired trichomegaly with topiramate

Santmyire-Rosenberger, Beth R.; Albert, Moses

doi:10.1016/j.jaad.2005.01.121

Cited by 24 publications

(23 citation statements)

References 11 publications

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“…For example, Santmyire-Rosenberger and Albert50 reported a case of trichomegaly in a 25-year-old bipolar patient who had been administered TPM 400 mg/day for 4 months. Also, in Fraunfelder et al’s report, two patients with blepharospasm were presented, one of whom showed a positive rechallenge test 23.…”

Section: Tpm Ophthalmologic Complicationsmentioning

confidence: 99%

Topiramate and the vision: a systematic review

Abtahi¹,

Abtahi²,

Fazel³

et al. 2012

OPTH

106

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Background and purposeTopiramate (TPM) is a sulfa-derivative monosaccharide that is used mainly for treating epilepsy and preventing migraine. Within the gamut of side effects attributable to this drug, ophthalmologic manifestations are of crucial importance. In this study, for the first time, the aim was to provide a systematic literature review regarding this issue.MethodsFor the time period 1996–2011, a PubMed search was made for the studies concerning the adverse/beneficial effects of TPM on vision. Overall, 404 citations out of a total of 2756 TPM-related studies were examined for relevance.ResultsA total of 74 relevant studies were reviewed, 65 of which comprise small observational studies describing the ophthalmic side effects of TPM in 84 patients. Of these patients, 66 were affected by ciliochoroidal effusion syndrome as the cardinal ocular side effect of TPM (17 cases of myopic shift and 49 cases of angle closure glaucoma). A comprehensive statistical analysis is provided on these 66 subjects. Other rare side effects of TPM on the vision were also reviewed, including massive choroidal effusion, ocular inflammatory reactions, visual field defects, probable effects on retina, cornea, and sclera, and neuroophthalmologic complications. In addition, a framework is provided to classify these results.DiscussionDue to the expanding spectrum of indications for the administration of TPM, neurologists and psychiatrists should be aware of its diverse ocular side effects. In conclusion, ocular complications following this drug should be taken seriously and be subjected to ophthalmic counseling.

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Section: Tpm Ophthalmologic Complicationsmentioning

confidence: 99%

Topiramate and the vision: a systematic review

Abtahi¹,

Abtahi²,

Fazel³

et al. 2012

OPTH

106

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“…608 The abnormality can be reproduced by heat, suggesting that hair dryers that overheat may be responsible. 140,612,613 A variant associated with mental retardation and retinal degeneration (OMIM 275400) also occurs. It may be associated with more generalized hypertrichosis or with involvement of the eyebrows as well.…”

Section: Bubble Hairmentioning

confidence: 99%

Diseases of cutaneous appendages

Weedon

2010

Weedon's Skin Pathology

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“…During embryological development, eyelashes are the first terminal hairs to appear. Their growth cycle lasts approximately 5–6 months, consisting of 30 days in the anagen phase, 15 days in the catagen phase, and over 100 days in the telogen phase 5 . In comparison to scalp hair, eyelashes have a low ratio of anagen to telogen hair follicles, with approximately 50% of eyelashes in the anagen phase at all times compared with 85–90% of scalp hairs 5,12 …”

Section: Eyelash Growthmentioning

confidence: 99%

Eyelash trichomegaly: review of congenital, acquired, and drug‐associated etiologies for elongation of the eyelashes

Paul¹,

Cohen

Kurzrock

2012

Int J Dermatology

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Eyelash trichomegaly is defined as eyelashes which are found to be of increased length, thickness, and pigmentation. This unique finding can be present at birth as part of a variety of congenital syndromes or as a benign familial trait. There are also acquired conditions and drugs that are known to cause these changes. Case reports and clinical studies in the medical literature concerning eyelash trichomegaly were investigated and summarized to compile a comprehensive review of the etiology of eyelash trichomegaly. Previously published reviews and studies that report on the finding of increased generalized hair growth and which do not specifically mention eyelashes were not included. Trichomegaly of the eyelashes may occur as a key feature among rare congenital syndromes, develop in association with certain acquired diseases, or present as an intended or treatment-related adverse drug effect. Eyelash trichomegaly may be present from birth or manifest later in life in association with acquired diseases or drug therapy. The relevance of this finding may be benign, however eyelash trichomegaly in some individuals can be a symptom for immune dysfunction or a clinical measure of response to drug therapy.

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Acquired trichomegaly with topiramate

Cited by 24 publications

References 11 publications

Topiramate and the vision: a systematic review

Topiramate and the vision: a systematic review

Diseases of cutaneous appendages

Eyelash trichomegaly: review of congenital, acquired, and drug‐associated etiologies for elongation of the eyelashes

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