Acquired Skin Fragility Syndrome with Systemic Amyloidosis in a Cat

Abstract

A 9-year-old, male neutered domestic shorthair cat was presented with injury at the hip. The skin was markedly thin and it was easily damaged with minor trauma. Complete blood counts showed anemia and neutrophilia with the left shift. Histopathology revealed severely atrophic epidermis with hyperkeratosis, and atrophic dermis consisted of dispersed collagen fibers. The cat was diagnosed as having acquired skin fragility syndrome. After fifty-four days, the cat suddenly died, and autopsy showed systemic amyloidosis with lipid pneumonia and interstitial nephritis.