Acquired sensorineural hearing loss in children: current research and therapeutic perspectives

Ralli, Massimo; Rolesi, Rolando; Anzivino, Roberta; Turchetta, Rosaria; Fetoni, Anna Rita

doi:10.14639/0392-100x-1574

Cited by 14 publications

(4 citation statements)

References 82 publications

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“…Given the ototoxicity of cisplatin, antioxidants are the appropriate group of substances to help prevent ototoxicity due to cisplatin (TABLE 2). 21,27…”

Section: Resultsmentioning

confidence: 99%

Protective role of Nigella sativa oil against cisplatin-induced ototoxicity: a literature review

Hendriyanto

Helmi

2023

JMedScie

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Cisplatin is widely used for the chemotherapy of head and neck cancer. However, it has a significant ototoxicity. Nigella sativa has been scientifically proven to have numerous benefits included to prevent adverse effect of a drug. This literature review aimed to evaluate the protective role of N. sativa oil against cisplatin-induced ototoxicity. Relevant publications were searched from PubMed and Google Scholar databases within the last 10 years. Ototoxicity due to cisplatin can occur through the intrinsic and extrinsic pathways. Cisplatin causes endoplasmic reticulum stress, DNA damage, increased reactive oxygen species (ROS) and inflammatory processes, resulting in increased apoptosis of cochlear outer hair cells. The active constituents of N. sativa including flavonoids, phenolics and thymoquinone can prevent the cisplatin-induced ototoxicity. Examination of endogenous antioxidants, antiapoptotic, and proinflammatory could be used as primary approach to evaluate the protective role of N. sativa against cisplatin-induced ototoxicity.

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“…Given the ototoxicity of cisplatin, antioxidants are the appropriate group of substances to help prevent ototoxicity due to cisplatin (TABLE 2). 21,27…”

Section: Resultsmentioning

confidence: 99%

Protective role of Nigella sativa oil against cisplatin-induced ototoxicity: a literature review

Hendriyanto

Helmi

2023

JMedScie

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“…The common key event of the diverse risk factors (e.g., noise, smoking, toxic substances, diabetes) in developing hearing loss is via the production of reactive oxygen species, ROS [ 13 , 40 , 41 ]. Excessive production of ROS species may induce mitochondrial DNA mutations with resulting cochlear cell apoptosis [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Hearing Loss and Urinary trans,trans-Muconic Acid (t,t-MA) in 6- to 19-Year-Old Participants of NHANES 2017–March 2020

Benedict,

Scinicariello,

Abadin

et al. 2024

Toxics

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Hearing loss (HL) is associated with poorer language development and school performance. Ototoxic substances such as metals and solvents, including benzene, are a risk factor associated with HL. This study examines potential associations between the benzene metabolite trans,trans-muconic acid (t,t-MA) and HL in youth of the National Health and Nutrition Examination Survey (NHANES). Logistic regression calculated adjusted odds ratio (aOR) associations between HL and urinary t,t-MA quartiles, natural-log transformed, and doubled urinary t,t-MA. Hearing threshold pure-tone average (PTA) at speech frequencies (SF) 0.5, 1, 2, and 4 kHz and high frequencies (HF) 3, 4, and 6 kHz were analyzed for slight HL (PTA > 15 dB) and mild HL (PTA > 20 dB). Urinary t,t-MA was statistically significantly associated with both slight SF and HF HL. For each doubling of t,t-MA there were increased odds of having slight SFHL (aOR = 1.42; 95% CI: 1.05, 1.92), slight HFHL (aOR = 1.31; 95% CI: 1.03, 1.66), mild SFHL (aOR = 1.60; 95% CI: 1.10, 2.32), and mild HFHL (aOR = 1.45; 95% CI: 1.03, 2.04). To our knowledge, this is the first population-based report of an association between SFHL, HFHL, and the benzene metabolite t,t-MA in youth 6 to 19 years old.

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“…Nanoparticles can keep genes or drugs in the body and protect them from enzyme damage. Innovative methods include introducing specific genes into cells to produce proteins or compensate for abnormal genes or gene transfection [ 43 ].…”

Section: The Role Of Nanoparticles In Gene Therapy Of the Inner Earmentioning

confidence: 99%

Nanomaterials for Inner Ear Diseases: Challenges, Limitations and Opportunities

Luo

Lin

et al. 2022

Materials

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The inner ear is located deep in the temporal bone and has a complex anatomy. It is difficult to observe and obtain pathological tissues directly. Therefore, the diagnosis and treatment of inner ear diseases have always been a major clinical problem. The onset of inner ear disease can be accompanied by symptoms such as hearing loss, dizziness and tinnitus, which seriously affect people’s lives. Nanoparticles have the characteristics of small size, high bioavailability and strong plasticity. With the development of related research on nanoparticles in inner ear diseases, nanoparticles have gradually become a research hotspot in inner ear diseases. This review briefly summarizes the research progress, opportunities and challenges of the application of nanoparticles in inner ear diseases.

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Acquired sensorineural hearing loss in children: current research and therapeutic perspectives

Cited by 14 publications

References 82 publications

Protective role of Nigella sativa oil against cisplatin-induced ototoxicity: a literature review

Protective role of Nigella sativa oil against cisplatin-induced ototoxicity: a literature review

Hearing Loss and Urinary trans,trans-Muconic Acid (t,t-MA) in 6- to 19-Year-Old Participants of NHANES 2017–March 2020

Nanomaterials for Inner Ear Diseases: Challenges, Limitations and Opportunities

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