Acquired Robertsonian translocations are not rare events in acute leukemia and lymphoma

Is there an association with constitutional structural chromosomal abnormalities and hematologic neoplastic process? A short review

“…Moreover, acquired Robertsonian translocations have been reported in hematologic malignancies. Welborn [36] reported 237 patients with hematologic malignancies (from the literature and their series) who had an acquired Robertsonian translocation.…”

Donor-derived constitutional chromosomal abnormalities after allogeneic hematopoietic cell transplantation: a single-center experience and a review of the literature

“…In addition, acquired Robertsonian translocations may be found in hematological disorders at a higher frequency of 1 in 300-400. 7 Graze et al 8 reported a case of phenotypically normal donor with a t (18;22) constitutional chromosome translocation. There was also another case of Robertsonian constitutional translocation noted from a donor (sister) with t(14;15) in a male recipient with CML.…”

Inadvertent transplantation of haematopoietic stem cells carrying constitutional Robertsonian translocation from an apparently normal donor to an AML patient: a case report

“…In such cases they are acquired cytogenetic aberrations and almost always result in a trisomic karyotype that could contribute to clonal evolution of the underlying neoplastic disease. [2][3][4] We report a case of transplantation of haematopoietic stem cells (HSCs) bearing RTs from an apparently healthy BM donor to a recipient with AML.…”

“…However, acquired RTs are also found in haematological malignancies with a frequency estimated at 1 in 300-400 patients. 4 In this case report, we describe the transmission of a constitutional RT from an unrelated, apparently healthy donor to a patient with AML who received an allogeneic BMT. The translocation found in the donor was most likely a constitutional abnormality, as it was not linked to any haematopoietic disease and was found as the only aberration.…”