Acquired resistance in dogs to repeated infestation with Ixodes scapularis (Acari: Ixodidae) reduces tick viability and reproductive success

Gebbia, Joseph A.; Bosler, Edward M.; Evans, Robert D.; Schneider, Edward M.

doi:10.1007/bf00048814

Cited by 18 publications

(13 citation statements)

References 19 publications

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“…131 The immune responses recruited to the tick bite site on tick-resistant animals are thought to be detrimental to tick feeding resulting in early tick detachment and decreased engorgement weights. Similar observations with additional tick species, as well as the generation of ATR in rabbits, mice and cattle [132][133][134][135] have demonstrated that the phenomenon of ATR is widespread in tick-host interactions.…”

Section: Animal Model S Of Acqu Ired Tick Re S Is Tan Cesupporting

confidence: 73%

Acquired tick resistance: The trail is hot

Narasimhan

Kurokawa

DeBlasio

et al. 2020

Parasite Immunology

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Acquired tick resistance is a phenomenon wherein the host elicits an immune response against tick salivary components upon repeated tick infestations. The immune responses, potentially directed against critical salivary components, thwart tick feeding, and the animal becomes resistant to subsequent tick infestations. The development of tick resistance is frequently observed when ticks feed on non-natural hosts, but not on natural hosts. The molecular mechanisms that lead to the development of tick resistance are not fully understood, and both host and tick factors are invoked in this phenomenon. Advances in molecular tools to address the host and the tick are beginning to reveal new insights into this phenomenon and to uncover a deeper understanding of the fundamental biology of tick-host interactions. This review will focus on the expanding understanding of acquired tick resistance and highlight the impact of this understanding on anti-tick vaccine development efforts.

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Section: Animal Model S Of Acqu Ired Tick Re S Is Tan Cesupporting

confidence: 73%

Acquired tick resistance: The trail is hot

Narasimhan

Kurokawa

DeBlasio

et al. 2020

Parasite Immunology

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“…Canines experimentally infested with adult I. scapularis developed acquired resistance, which reduced tick viability and oviposition with each successive exposure (11). Acquired resistance to the vector might reduce transmission of spirochetes.…”

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confidence: 99%

Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks

et al. 1997

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Female BALB/c mice were infested four times with pathogen-free Ixodes scapularis nymphs prior to infestation with nymphs infected with Borrelia burgdorferi B31. Each infestation was separated by a 14-day tick-free period. Mean weights of fed ticks and percentage reaching repletion did not indicate development of acquired resistance. Only 16.7% of mice repeatedly infested with pathogen-free ticks prior to infected I. scapularis nymph challenge became positive for B. burgdorferi. One hundred percent of control mice infested only with infected ticks were culture positive for B. burgdorferi.

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“…Some differences between the results obtained by the above-mentioned authors and the results of the present study (the percentage of normally hatched larvae) stem from the different degree of host immunisation (different re-infestation time) and from different methodologies employed (different experimental conditions). In I. scapularis feeding on immunised dogs, oviposition disturbances and decreased larval survival in the first generation were observed [46]. The current results suggest that co-feeding 2 different tick species on the same host may partially counteract the adverse influence of host immunity in repeated invasions.…”

Section: Discussionmentioning

confidence: 55%

Study of the non-parasitic stage in Ixodes ricinus after co-feeding with Dermacentor reticulatus in three infestations

Bartosik

Buczek

Borzęcki³

et al. 2017

Ann Agric Environ Med.

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It was proved that transmission of some pathogens may occur between infected and uninfected ticks co-feeding on a host in the absence of systemic infection. The effect was studied of co-feeding of two different tick species Ixodes ricinus and Dermacentor reticulatus on the course of the non-parasitic stage. Species chosen for the experiment may share their habitats and co-infest animals in nature. In the course of the study the process of egg maturation, oviposition and larval hatching were investigated. In order to estimate if co-feeding influence can counteract host immunity, three subsequent infestations of rabbits were analyzed. Mono-specific groups values of such a parameters as egg amount, number of eggs per 1 mg of female engorgement weight, female oviposition weight loss, hatching success were higher in inter-specific groups were compared. The results indicate that co-feeding with other tick species may partially reduce the influence of host resistance in subsequent infestation.

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Acquired resistance in dogs to repeated infestation with Ixodes scapularis (Acari: Ixodidae) reduces tick viability and reproductive success

Cited by 18 publications

References 19 publications

Acquired tick resistance: The trail is hot

Acquired tick resistance: The trail is hot

Infestation with pathogen-free nymphs of the tick Ixodes scapularis induces host resistance to transmission of Borrelia burgdorferi by ticks

Study of the non-parasitic stage in Ixodes ricinus after co-feeding with Dermacentor reticulatus in three infestations

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