Acquired pit of the optic nerve: A risk factor for progression of glaucoma

Uğurlu, Şeyda; Weitzman, Marc; Nduaguba, Constance

doi:10.1016/s0002-9394(99)80185-8

Cited by 48 publications

(45 citation statements)

References 8 publications

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“…The prevalence of APON in glaucomatous eyes was 2.8% to 6.6%. [33][34][35][36] In the current study, the prevalence of APON was 3.3%, almost consistent with these earlier studies. It was uncertain whether lamina cribrosa defects and APON are identical, different, or overlapped.…”

Section: Discussionsupporting

confidence: 92%

“…The APON was reportedly more frequently located inferiorly [34][35][36] and was associated with visual field defects, [33][34][35][36] visual field progression, 34 and disc hemorrhages. 34,36 Thus, focal lamina cribrosa defects and APON appear to have similar clinical characteristics. However, in the current study, focal lamina cribrosa defects were a little more prevalent (6.6%) and found only in 1 of the 6 eyes with APON.…”

Section: Discussionmentioning

confidence: 98%

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Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Takayama

Hangai

Kimura

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 98%

Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Takayama

Hangai

Kimura

et al. 2013

Invest. Ophthalmol. Vis. Sci.

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“…Bochmann et al compared CH measurements in glaucoma patients and patients with acquired pit of the optic nerve head (APON). The latter condition mainly occurs in normotensive glaucoma and is associated with higher risk of progressive optic disc damage (19 (20). This finding also shows that lower CH could be marker for possible susceptibility of the optic nerve to glaucomatous damage, independent of CCT.…”

Section: Discussionmentioning

confidence: 62%

“…19), but mean IOPcc of glaucoma group was significantly higher than seen in healthy macrodisc or control group (p=0.024, p=0.003, respectively). CH of glaucoma patients was lower than that of healthy macrodisc group or control group (p=0.048, p=0.035, respectively), whereas, mean CH of macrodisc group was similar to that of control group (p=0.988).…”

Section: Resultsmentioning

confidence: 77%

Comparison of Corneal Biomechanical Properties Betweeen Physiological Macrodiscs and Glaucomatous Macrodiscs

Onmez¹

2017

Beyoglu Eye J

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Objectives:This study was designed to compare optic nerve head (ONH) parameters and corneal biomechanical properties of healthy and glaucomatous macrodiscs. Methods: This cross-sectional study included total of 234 eyes, of which 92 served as normal controls, 92 had healthy macrodiscs, and 50 had glaucomatous macrodiscs. Measurement of ONH parameters in all p¬atients was performed using optic coherence tomography (OCT). Corneal hysteresis (CH) was measured in each patient using Ocular Response Analyzer (ORA; Reichert, Inc., Depew, NY, USA). Central corneal thickness (CCT) was determined by ultrasonic pachymetry. All OCT and ORA parameters of healthy and glaucomatous macrodiscs were compared. Results: Optic disc area of healthy macrodiscs and glaucomatous macrodiscs was similar, and larger than observed in control group (p=0.70, p=0.0001, respectively). Rim area was significantly thinner in glaucoma group than healthy macrodisc group or control group. (p=0.0001, p=0.022, respectively) Mean cup area of glaucomatous discs was larger than healthy macrodiscs (p=0.001). Cup/disc (C/D) area ratio, and horizontal and vertical C/D ratios were higher in glaucoma group than healthy macrodisc group (p=0.002, p=0.002, p=0.018, respectively) ORA analyses revealed that CH of glaucoma patients was lower than that of healthy macrodisc or control group (p=0.048, p=0.035, respectively), whereas, mean CH of macrodisc group was similar to that of control group (p=0.988). Mean CCT of macrodisc group was higher than that observed in control or glaucoma patients (p=0.015, p=0.045). Conclusion: It was concluded that OCT analyses can help differentiate healthy macrodiscs from glaucomatous discs. CH and corneal thickness measurements of healthy macrodiscs are greater than those of glaucomatous optic discs.

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“…Subsequent studies have also found similar and additional characteristics in patients with senile sclerotic discs. 81,85,90,91 …”

Section: Senile Sclerotic Discsmentioning

confidence: 99%

Normal Pressure Glaucoma

Prum

2010

The Glaucoma Book

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Acquired pit of the optic nerve: A risk factor for progression of glaucoma

Cited by 48 publications

References 8 publications

Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Three-Dimensional Imaging of Lamina Cribrosa Defects in Glaucoma Using Swept-Source Optical Coherence Tomography

Comparison of Corneal Biomechanical Properties Betweeen Physiological Macrodiscs and Glaucomatous Macrodiscs

Normal Pressure Glaucoma

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