Acquired pendular nystagmus

Kang, Sarah L.; Shaikh, Aasef G.

doi:10.1016/j.jns.2017.01.033

Cited by 26 publications

(17 citation statements)

References 67 publications

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“…The prevalence of the well-described pendular nystagmus 9,32 was exceedingly rare in our group, namely, at 0.5%. This one subject showed that this type of nystagmus can be a very distressing oculomotor finding in MS, with continuous visual complaints that interfere with daily activities.…”

Section: Discussioncontrasting

confidence: 52%

“…Well-known causes are pendular nystagmus and internuclear ophthalmoplegia. 3,[9][10][11] Furthermore, abnormalities of eye movements are associated with greater general disability in MS. 12,13 Hitherto, studies describing the extensive range of abnormalities were essentially based on clinical examination. 6,[14][15][16][17] It stands to reason that the clinical diagnosis of many eye movement disorders is difficult and can be challenging.…”

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confidence: 99%

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Quantification of Visual Fixation in Multiple Sclerosis

Bijvank

Petzold

Coric

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. Eye movement abnormalities are common in multiple sclerosis (MS), and infrared oculography is a noninvasive method for quantification. This study aims to describe and classify abnormalities of visual fixation and their clinical relevance in MS. METHODS. A validated standardized infrared oculography protocol, Demonstrate Eye Movement Networks with Saccades, was used for quantifying gaze stability during a fixation task in MS patients and healthy controls. Saccadic intrusions, gaze drift, and stability of fixation around the drift line were used to subclassify MS patients by performing receiver operating characteristic analyses of different parameters. The relationship between the presence of abnormalities of fixation and visual functioning was analyzed using logistic regression models, which was adjusted for possible confounders. RESULTS. This cross-sectional study included 213 subjects with MS and 57 healthy controls. Square wave jerk abnormalities were present in 24% of MS patients. The prevalence was higher in more disabled subjects. The presence of larger square wave jerks (with a higher amplitude) in the MS patients was related to complaints of focusing on stationary objects (odds ratio, 2.2; P ¼ 0.035) and a lower vision-related quality of life (odds ratio, 2.56; P ¼ 0.012). CONCLUSIONS. This study provided a comprehensive overview of the characteristics of problems with visual fixation in subjects with MS. The most important and most common finding was the presence of larger square wave jerks during fixation, which was related to visual functioning in daily life.

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Section: Discussioncontrasting

confidence: 52%

mentioning

confidence: 99%

Quantification of Visual Fixation in Multiple Sclerosis

Bijvank

Petzold

Coric

et al. 2019

Invest. Ophthalmol. Vis. Sci.

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“…Another barrier, especially in low-income countries (where telerehabilitation would be most needed), is the lack of technological infrastructure. A cross-sectional study (on 100 stroke survivors) in a Ghanaian outpatient neurology clinic demonstrated that 80%-93% of patients had a positive attitude toward telerehabilitation interventions; however, only 35% of them had smartphones [ 29 ]. Further development of telerehabilitation networks is essential to overcome these barriers [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Telerehabilitation for Stroke Survivors: Systematic Review and Meta-Analysis

Tchero¹,

et al. 2018

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BackgroundTelerehabilitation is an emerging technology through which medical rehabilitation care can be provided from a distance.ObjectiveThis systematic review and meta-analysis aims to investigate the efficacy of telerehabilitation in poststroke patients.MethodsEligible randomized controlled trials (RCTs) were identified by searching MEDLINE, Cochrane Central, and Web of Science databases. Continuous data were extracted for relevant outcomes and analyzed using the RevMan software as the standardized mean difference (SMD) and 95% CI in a fixed-effect meta-analysis model.ResultsWe included 15 studies (1339 patients) in our systematic review, while only 12 were included in the pooled analysis. The combined effect estimate showed no significant differences between the telerehabilitation and control groups in terms of the Barthel Index (SMD –0.05, 95% CI –0.18 to 0.08), Berg Balance Scale (SMD –0.04, 95% CI –0.34 to 0.26), Fugl-Meyer Upper Extremity (SMD 0.50, 95% CI –0.09 to 1.09), and Stroke Impact Scale (mobility subscale; SMD 0.18, 95% CI –0.13 to 0.48]) scores. Moreover, the majority of included studies showed that both groups were comparable in terms of health-related quality of life (of stroke survivors), Caregiver Strain Index, and patients’ satisfaction with care. One study showed that the cost of telerehabilitation was lower than usual care by US $867.ConclusionsTelerehabilitation can be a suitable alternative to usual rehabilitation care in poststroke patients, especially in remote or underserved areas. Larger studies are needed to evaluate the health-related quality of life and cost-effectiveness with the ongoing improvements in telerehabilitation networks.

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“…In fact, these oscillations remain unchanged in darkness when visual inputs have no influence on eye movements. Since the oscillations of APN are reset by large saccades, which produce a phase shift of the oscillation ( 22 ), it is more likely that APN originates within the neural integrator network in the brain stem and cerebellum ( 23 ). The premotor signal responsible for large saccades would basically reset the APN oscillations by silencing some neural integrator neurons that produce the nystagmus.…”

Section: Eye Movement Disorders In Msmentioning

confidence: 99%

Eye Movement Abnormalities in Multiple Sclerosis: Pathogenesis, Modeling, and Treatment

2018

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Multiple sclerosis (MS) commonly causes eye movement abnormalities that may have a significant impact on patients’ disability. Inflammatory demyelinating lesions, especially occurring in the posterior fossa, result in a wide range of disorders, spanning from acquired pendular nystagmus (APN) to internuclear ophthalmoplegia (INO), among the most common. As the control of eye movements is well understood in terms of anatomical substrate and underlying physiological network, studying ocular motor abnormalities in MS provides a unique opportunity to gain insights into mechanisms of disease. Quantitative measurement and modeling of eye movement disorders, such as INO, may lead to a better understanding of common symptoms encountered in MS, such as Uhthoff’s phenomenon and fatigue. In turn, the pathophysiology of a range of eye movement abnormalities, such as APN, has been clarified based on correlation of experimental model with lesion localization by neuroimaging in MS. Eye movement disorders have the potential of being utilized as structural and functional biomarkers of early cognitive deficit, and possibly help in assessing disease status and progression, and to serve as platform and functional outcome to test novel therapeutic agents for MS. Knowledge of neuropharmacology applied to eye movement dysfunction has guided testing and use of a number of pharmacological agents to treat some eye movement disorders found in MS, such as APN and other forms of central nystagmus.

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Acquired pendular nystagmus

Cited by 26 publications

References 67 publications

Quantification of Visual Fixation in Multiple Sclerosis

Quantification of Visual Fixation in Multiple Sclerosis

Telerehabilitation for Stroke Survivors: Systematic Review and Meta-Analysis

Eye Movement Abnormalities in Multiple Sclerosis: Pathogenesis, Modeling, and Treatment

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