Acquired neuropathies

Lozeron, Pierre; Trocello, Jean‐Marc; Kubis, Nathalie

doi:10.1007/s00415-013-6994-z

Cited by 4 publications

(2 citation statements)

References 67 publications

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“…Seltener sind toxische Neuropathien. Trotz umfangreicher Diagnostik inklusive Nervenbiopsie bleibt die Ursache der PN in 30-40 % ungeklärt [1,2]. Diese Arbeit soll einen komprimierten Überblick über die erworbenen immunvermittelten / inflammatorischen PN geben und diagnostische Strategien vermitteln, die klinische Besonderheiten, neuere Erkenntnisse und Antikörper-Screening berücksichtigen.…”

Section: Erworbene Neuropathienunclassified

Immunvermittelte / inflammatorische und hereditäre Neuropathien – Übersicht und diagnostischer Algorithmus

Schlotter‐Weigel

Senderek

2018

Fortschr Neurol Psychiatr

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ZusammenfassungDiese Arbeit gibt eine praxisnahe Übersicht über immunvermittelte / inflammatorische und hereditäre Neuropathien mit Empfehlungen zur weiterführenden Diagnostik. Zur großen Gruppe der immunvermittelten / inflammatorischen Neuropathien zählen u. a. das Guillain-Barré-Syndrom und die chronisch-inflammatorische demyelinisierende Polyradikuloneuropathie mit ihren Subtypen, die vaskulitischen, paraneoplastischen, paraproteinämischen und die Kollagenose-assoziierten Neuropathien. Neben den klinischen Besonderheiten wie zeitlichem Verlauf und Verteilungstyp werden charakteristische Befunde der Elektroneurografie und Antikörper-Diagnostik berücksichtigt. Bei den hereditären Neuropathien sprechen neue Studien für eine Prävalenz von 10–28 pro 100 000 Einwohner in Europa. In den letzten 20 Jahren hat die molekulargenetische Diagnostik bei hereditären Neuropathien große Fortschritte gemacht. Mittlerweile sind über 80 Neuropathie-Gene bekannt. Neben der elektroneurografischen Einteilung in demyelinisierende, axonale und intermediäre Formen sind die Unterscheidung in sensomotorische, motorische, sensible oder autonom-sensible Neuropathien sowie die Berücksichtigung von klinischen Besonderheiten und ethnischer Zugehörigkeit hilfreich für die Bahnung der molekulargenetischen Diagnostik.

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Section: Erworbene Neuropathienunclassified

Immunvermittelte / inflammatorische und hereditäre Neuropathien – Übersicht und diagnostischer Algorithmus

Schlotter‐Weigel

Senderek

2018

Fortschr Neurol Psychiatr

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“…Of these systems, the peripheral nervous system (PNS) is the most critical target. Arsenic neuropathy is characterized by sensory disorders, which are more frequent and more serious than motor impairments [4]. In occupational exposure, As effects are usually combined with carcinogenicity [3].…”

Section: Introductionmentioning

confidence: 99%

Neurological and neurophysiological examinations of workers exposed to arsenic levels exceeding hygiene standards

Sińczuk-Walczak¹,

Janasik²,

Trzcinka-Ochocka³

et al. 2014

IJOMEH

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Objectives: The assessment of the neurotoxic effect of arsenic (As) and its inorganic compounds is still the subject of interest due to a growing As application in a large array of technologies and the need to constantly verify the principles of prevention and technological parameters. The aim of this study was to determine the status of the nervous system (NS) in workers exposed to As at concentrations exceeding hygiene standards (Threshold Limit Values (TLV) -10 μg/m 3 , Biological Exposure Index (BEI) -35 μg/l) and to analyze the relationship between the NS functional state, species of As in urine and As levels in the workplace air. Material and Methods: The study group comprised 21 men (mean age: 47.43±7.59) employed in a copper smelting factory (mean duration of employment: 22.29±11.09). The control group comprised 16 men, matched by age and work shifts. Arsenic levels in the workplace air (As-A) ranged from 0.7 to 92.3 μg/m 3 ; (M = 25.18±28.83). The concentration of total arsenic in urine (As tot -U) ranged from 17.35 to 434.68 μg/l (M = 86.82±86.6). Results: Syndrome of peripheral nervous system (PNS) was manifested by extremity fatigue (28.6%), extremity pain (33.3%) and paresthesia in the lower extremities (33.3%), as well as by neuropathy-type mini-symptoms (23.8%). Electroneurographic (ENeG) tests of peroneal nerves showed significantly decreased response amplitude with normal values of motor conduction velocity (MCV). Stimulation of sural nerves revealed a significantly slowed sensory conduction velocity (SCV) and decreased sensory potential amplitude. Neurophysiological parameters and the results of biological and environmental monitoring showed a relationship between As tot , As III (trivalent arsenic), the sum of iAs (As III +As V (pentavalent arsenic))+MMA (monomethylarsonic acid) concentration in urine and As levels in the air. Conclusions: The results of the study demonstrate that occupational exposure to inorganic arsenic levels exceeding hygiene standards (TLV, BEI) generates disorders typical of peripheral neuropathy.

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Recent advances in the neuroimmunology of cell-surface CNS autoantibody syndromes, Alzheimer’s disease, traumatic brain injury and schizophrenia

Zandi

2014

J Neurol

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In this update, we review recent advances in antibody-associated disorders of the central nervous system, and the immune mechanisms which may contribute to Alzheimer's disease, traumatic brain injury and schizophrenia. The field of neuroimmunology is rapidly developing and has concerned itself with an expanding portfolio of diseases. The core neuroimmunological diseases remain, multiple sclerosis, neuromyelitis optica, primary inflammatory and antibody-associated disorders of the central and peripheral nervous system (including Myasthenia Gravis and other disorders of neuromuscular junction and muscle, paraneoplastic syndromes, paraproteinaemic neuropathies), and the neurological involvement seen in systemic inflammatory diseases including lupus, sarcoidosis and vasculitis. But it is increasingly realised that immune mechanisms may contribute to the pathogenesis of degenerative diseases including Alzheimer's disease, traumatic brain disease and psychiatric diseases including schizophrenia and depression. These common and devastating disorders, often without effective disease-modifying therapies, are yet to be seen in a conventional neuroimmunology clinic, but the immune mechanisms identified have encouraged research into novel therapeutic approaches for them.

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Acquired neuropathies

Cited by 4 publications

References 67 publications

Immunvermittelte / inflammatorische und hereditäre Neuropathien – Übersicht und diagnostischer Algorithmus

Immunvermittelte / inflammatorische und hereditäre Neuropathien – Übersicht und diagnostischer Algorithmus

Neurological and neurophysiological examinations of workers exposed to arsenic levels exceeding hygiene standards

Recent advances in the neuroimmunology of cell-surface CNS autoantibody syndromes, Alzheimer’s disease, traumatic brain injury and schizophrenia

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