Acquired Immunodeficiency Syndrome in the Child of a Haemophiliac

Relationship between antibody production to Epstein-Barr virus (EBV) early antigens and various EBV-related diseases

“…An enhanced IgG response to EAs or VCAs has been found in homosexual men [71] and particularly in AIDS cases [70,77]. In patients developing OHL, elevated titers of VCA-specific IgG were observed, while anti-EA IgG and EBNA antibody levels resembled those of healthy non-homosexual individuals [30].…”

The natural history of human T lymphotropic virus-III infection: the cause of AIDS.

“…Some people who are antibody positive have as their only likely risk factors promiscuity and sexual contact with prostitutes.72 PERINATAL TRANSMISSION Infants with either symptomatic or asymptomatic HTLV-III infection are mostly the offspring of parents at high risk of AIDS.7778 Indeed, most such infants have been born to BRITISH MEDICAL JOURNAL VOLUME 292 4 JANUARY 1986 parenteral drug users or Haitians, but cases have also been reported in families where the mothers were infected by their spouses. 79 In most cases transmission from mother to child probably takes place before delivery,80 but in one instance infection may have occurred postnatally through breast milk.8' AIDS in childhood is seen mostly in infancy and the first years of life and is rare in older children, which further argues for perinatal rather than casual transmission.82 With the increase in seropositivity among certain groups of females, it is a high priority to assess the risk of vertical transmission and the outcome of the disease among infected children. The available data are not encouraging.…”

Hemophiliac patient's knowledge and educational needs concerning acquired immunodeficiency syndrome

“…4. At least one case of neonatal AIDS has been reported in a child of a hemophilic patient who subsequently developed AIDS himself [7].…”