Acquired immune dysfunction in homosexual men: Immunologic profiles

Ammann, Arthur J.; Abrams, Donald I.; Conant, Marcus A.; Chudwin, David S.; Cowan, Morton J.; Volberding, Paul A.; Lewis, Brian J.; Casavant, Conrad H.

doi:10.1016/0090-1229(83)90084-3

Cited by 160 publications

(30 citation statements)

References 15 publications

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“…High serum IgE in individuals with AIDS were seen at the beginning of the epidemic and confirmed years later by other studies (63)(64)(65)(66)(67)(68)(69). Some studies have found a relationship between high IgE levels and CD4 + T lymphocyte count < 300 cells/ mm 3 (64)(65)67).…”

Section: Discussionsupporting

confidence: 53%

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Amâncio¹,

Pascotto²,

Souza³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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This study applied a socioeconomic questionnaire designed to evaluate the frequency of intestinal parasites and characterize epidemiological, nutritional, and immunological variables in 105 HIV/AIDS patients -with and without parasitic infections, attending the Day Hospital in Botucatu, UNESP, from 2007 to 2008. Body mass index was calculated and the following tests performed: parasitological stool examinations; eosinophil, IgE, CD4 + T and CD8 + T lymphocyte cell counts; albumin test; viral load measure; and TNF-α, IFN-γ, IL-2, IL-5 and IL-10 cytokine levels. Results were positive for parasitic intestinal infections in 12.4% of individuals. Most patients had good socioeconomic conditions with basic sanitation, urban dwellings, treated water supply and sewage, good nutritional and immunological status and were undergoing HAART. Parasites were found at the following frequencies: Entamoeba -five patients (38.5%), Giardia lamblia -four (30.7%), Blastocystis hominis -three (23.0%), Endolimax nana -two (15.4%), and Ascaris lumbricoides -one (7.7%). There were no significant differences between the two groups for eosinophils, albumin, IgE, CD4 + T and CD8 + T lymphocytes, INF-γ, IL-2, or IL-10. Most patients also showed undetectable viral load levels. Significant differences were found for TNF-α and IL-5. These results show the importance of new studies on immunodeficient individuals to increase understanding of such variables.

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Section: Discussionsupporting

confidence: 53%

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Amâncio¹,

Pascotto²,

Souza³

et al. 2012

J. Venom. Anim. Toxins incl. Trop. Dis

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“…Previous reports ofimmune complexes in patients with AIDS present contradictory results (24)(25)(26)(27)(28)(29). This controversy could stem from the use ofdifferent assays to measure CIC.…”

Section: Resultsmentioning

confidence: 64%

“…In spite of the fact that immune complexes are apparently involved in AIDS-related thrombocytopenia (22) and glomerulitis (23), previous studies ofCIC are controversial (24)(25)(26)(27)(28)(29), and lack of complement activation has been reported (30)(31)(32). Complement activation, immune complexes, and their clearance by E-CR1 could influence some of the clinical manifestations of AIDS, therefore we studied these variables in homosexual subjects at varying risk of developing AIDS.…”

Section: Introductionmentioning

confidence: 99%

Altered erythrocyte C3b receptor expression, immune complexes, and complement activation in homosexual men in varying risk groups for acquired immune deficiency syndrome.

Tausk¹,

McCutchan²,

Spechko³

et al. 1986

J. Clin. Invest.

117

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We studied levels of erythrocyte C3b receptors (E-CR1) and correlated them to the level of circulating immune complexes (CIC) and complement activation in patients with or at risk for acquired immunodeficiency syndrome (AIDS). A significant reduction was found in patients with AIDS (185±93 CR1/cell), AIDS-related complex, and generalized lymphadenopathy, whereas healthy male homosexuals or normal controls had 434±193 and 509±140 CR1/cell, respectively (P < 0.001).Family studies indicate that this defect is acquired. Reduction in E-CR1 was associated with increased levels of CIC when assayed by binding to Raji cells, but not when tested by Clq binding. Complement activation was assessed by levels of C3bi/ C3d-g in plasma, measured with a monoclonal antibody specific for a neoantigen in C3d. AIDS patients had increased C3 activation (2.68±1.67%) when compared with normal controls (0.9±0.22%) (P < 0.01). The decreased E-CR1, the presence of CIC, and C3 activation suggest that complement activation by immune complexes may play a role in the clinical expression of the disease.

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“…In our view, the most reasonable (and conservative) interpretation of the isotype data is that the humoral immune response to HIV has the characteristics of a mature, ongoing, T-dependent response. (37)(38)(39), that levels decline with increasing duration of time since exposure (17,(37)(38)(39)(40)(41)(42), and that a low CD4 cell level is a poor-prognostic sign in HIV-infected persons (16,(39)(40)(41)(42)(43)(44)(45) The envelope glycoprotein gpl 10 participates in binding virus to the CD4 molecule (48) and is considered a likely target for interference with virus replication by antibody (4-6, 25, 29-31). In this context, it makes sense that lower anti-gpl 10 titers might predispose to more severe CD4 cell depletion and clinical AIDS.…”

Section: Resultsmentioning

confidence: 99%

Antibody response to human immunodeficiency virus in homosexual men. Relation of antibody specificity, titer, and isotype to clinical status, severity of immunodeficiency, and disease progression.

McDougal¹,

Kennedy²,

Nicholson³

et al. 1987

J. Clin. Invest.

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The titers and isotypes of antibodies to specific proteins of the human immodeficiency virus were determined by Western blot analysis of sera from 107 homosexual men.Antibody titers were generally lower in sera from patients with the acquired immudeficiency syndrome (AIDS) and in sera from men whose condition subsequently progressed to AIDS than in sera from men who had not progressed to AIDS. We found no evidence of isotypic prominence or restriction of the antibody response. In multivariate analysis, lower levels of CD4 helper cells were most highly associated with progression to AIDS. Lower antibody titers to the envelope protein gpllO, the core protein p24, and the reverse transeriptase enzyme p51/65 were also predictive of progression to AIDS independent of their Association with CD4 cell levels. These data suggest that differences in antibody levels are not simply a consequence of severe imnmunodeficiency but may be markers for control of infection.

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Acquired immune dysfunction in homosexual men: Immunologic profiles

Cited by 160 publications

References 15 publications

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Intestinal parasitic infections in HIV/AIDS patients: epidemiological, nutritional and immunological aspects

Altered erythrocyte C3b receptor expression, immune complexes, and complement activation in homosexual men in varying risk groups for acquired immune deficiency syndrome.

Antibody response to human immunodeficiency virus in homosexual men. Relation of antibody specificity, titer, and isotype to clinical status, severity of immunodeficiency, and disease progression.

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