Acquired ichthyosis and impaired dermal lipogenesis in Hodgkin's disease

Cooper, Mary F.; Wilson, P. D.; Hartop, P.J.; Shuster, Sam

doi:10.1111/j.1365-2133.1980.tb06570.x

Cited by 39 publications

(14 citation statements)

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“…These results, in agreement with previous studies on EC, point to the overlapping characteristics of EC and eczema and also help to exclude atypical ichthyosis [26, 27]. Distinguishing widespread EC from acquired ichthyosis may be an important issue, as the latter disease has been recognized as a paraneoplastic syndrome, most often associated with Hodgkin’s disease [25, 28]. In fact, the diagnosis of EC in its typical form is usually clinically obvious, even though ichthyosis and nummular eczema may occasionally be discussed as differential diagnosis [29].…”

Section: Discussionsupporting

confidence: 90%

Predictive Clinical Features of Eczema Craquelé Associated with Internal Malignancy

Sparsa¹,

Boulinguez²,

Liozon³

et al. 2007

Dermatology

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Objective: To describe a series of hospitalized patients with eczema craquelé (EC) and the possible correlations between clinical features of EC and cancer in an open prospective observational study. Patients and Interventions: The study population comprised 68 consecutive patients included between January 1, 1999 and December 31, 2000 who were followed up through December 2004. All patients who had localized or generalized EC were included. Patients underwent complete clinical examinations, routine laboratory tests, chest x-rays, abdominal ultrasound, and cutaneous biopsies performed on EC. Main Outcome Measures and Results: Rates of EC associated with cancer, clinical features of eczema, rate of recalcitrant eczema, relationship to other clinical prognostic factors, and paraneoplastic evolution were evaluated. Cancer was diagnosed in 32 patients (47%). We observed a significant difference in the presenting clinical signs of EC between patients with malignant tumors and patients without cancer. In patients with malignancies, EC was widespread on the trunk and we noted deep red and inflammatory fissures. In all cases, EC led to the discovery of malignancy or recurrence of cancer. Conclusion: Widespread EC, topical corticosteroid resistance, and deep red and inflammatory fissures were significantly correlated with neoplasia.

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Section: Discussionsupporting

confidence: 90%

Predictive Clinical Features of Eczema Craquelé Associated with Internal Malignancy

Sparsa¹,

Boulinguez²,

Liozon³

et al. 2007

Dermatology

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“…Approximately 80 cases of MPE have been reported in the English literature, and we analyzed the clinical characteristics of 57 cases [3,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33] based on information and articles we found in MEDLINE (table 1). The mean age of MPE patients was 59 years, with similar gender distribution, and the left pleural cavity was more commonly involved.…”

Section: Discussionmentioning

confidence: 99%

Multiple Myeloma with Myelomatous Pleural Effusion: A Case Report and Review of the Literature

Kim¹,

Kim²,

Min³

et al. 2008

Acta Haematol

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Multiple myeloma (MM) is a malignant neoplasm of plasma cell origin. Pleural effusion may develop in the setting of MM due to various reasons, but myelomatous pleural effusion (MPE) is rare. We report a case of MPE in a patient with advanced MM. A 76-year-old woman with MM was admitted to hospital because of dyspnea. Chest X-ray showed right-sided pleural effusion. Protein electrophoresis of the pleural fluid showed monoclonal protein, and cytology demonstrated monoclonal plasma cells. Hospice care was implemented, and the patient died one month later. We present an analysis of the clinical characteristics of 57 MPE cases reported in the English literature. Our review revealed that MPE patients had poor overall survival irrespective of whether MPE develops in the course of their disease or presents as the initial manifestation of MM. Based on this analysis, MPE is a poor prognostic factor, and aggressive treatment should be considered, especially for patients with early-onset MPE.

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“…Pruritus is a prominent feature in a quarter of patients and may be the presenting symptom, antedating the skin changes. Icthyosiform atrophy or acquired ichthyosis in an adult may also indicate HD [9,19]. Additionally, skin changes due to varicella-zoster virus (generalized herpes zoster) or to CMV have been found in patients with HD [20].…”

Section: Discussionmentioning

confidence: 99%