Acquired hemidystonia in childhood: A clinical and neuroradiological study of thirteen patients

Nardocci, Nardo; Zorzi, Giovanna; Grisoli, Marina; Rumi, V.; Broggi, Giovanni; Angelini, Lucia

doi:10.1016/0887-8994(96)00152-x

Cited by 26 publications

(15 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Limb dystonia is a hallmark of idiopathic torsion dystonia, with mutations in the DYT1 gene representing the commonest genetic basis. 1 However, it may also be seen with structural lesions involving the basal ganglia, including those due to trauma, stroke, and malignancy [2][3][4][5] and in the syndrome of fixed dystonia, 6 -8 which can also occur in the context of reflex sympathetic dystrophy 9 or the causalgiadystonia syndrome, 8 a condition in which a proportion of cases are likely to be psychogenic in etiology. 10,11 Here, we investigate whether the character of electromyographic (EMG) discharge may provide a clue to both pathophysiology and diagnosis in patients with dystonia in whom upper and lower limbs are affected.…”

mentioning

confidence: 98%

Patterns of EMG–EMG coherence in limb dystonia

et al. 2004

View full text Add to dashboard Cite

Dystonia of the limbs may be due to a wide range of aetiologies and may cause major functional limitation. We investigated whether the previously described pathological 4 to 7 Hz drive to muscles in cervical dystonia is present in patients with aetiologically different types of dystonia of the upper and lower limbs. To this end, we studied 12 symptomatic and 4 asymptomatic carriers of the DYT1 gene, 6 patients with symptomatic dystonia due to focal basal ganglia lesions, and 11 patients with fixed dystonia, a condition assumed to be mostly psychogenic in aetiology. We evaluated EMG-EMG coherence in the tibialis anterior (TA) of these and 15 healthy control subjects. Ten of 12 (83%) of symptomatic DYT1 patients had an excessive 4 to 7 Hz common drive to TA, evident as an inflated coherence in this band. This drive also involved the gastrocnemius, leading to co-contracting electromyographic bursts. In contrast, asymptomatic DYT1 carriers, patients with symptomatic dystonia, patients with fixed dystonia, and healthy subjects showed no evidence of such a drive or any other distinguishing electrophysiological feature. Moreover, the pathological 4 to 7 Hz drive in symptomatic DYT1 patients was much less common in the upper limb, where it was only present in 2 of 6 (33%) patients with clinical involvement of the arms. We conclude that the nature of the abnormal drive to dystonic muscles may vary according to the muscles under consideration and, particularly, with aetiology.

show abstract

mentioning

confidence: 98%

Patterns of EMG–EMG coherence in limb dystonia

et al. 2004

View full text Add to dashboard Cite

show abstract

“…Dystonia is very rare as a manifestation of APS, although basal ganglia involvement is common in PAPS. Delayed dystonia has been reported in children with secondary or primary antiphospholipid syndrome [13,14], and a case of focal hand dystonia and parkinsonism with basal ganglia lesions has been described by Milanov et al [4].…”

Section: Discussionmentioning

confidence: 96%

Complex movement disorders in primary antiphospholipid syndrome: A case report

Carecchio

Comi

Varrasi

et al. 2009

Journal of the Neurological Sciences

View full text Add to dashboard Cite

“…Hyperkinetic movement disorders may be disabling and are common after childhood AIS [189,190], particularly those involving the basal ganglia [113]. Headache disorders are also common, occurring in approximately one-third of stroke survivors [181].…”

Section: Childhood Ais Outcomesmentioning

confidence: 99%

Arterial Ischemic Stroke in Neonates and Children: Review and Current Issues

Kirton¹,

Hill²,

deVeber³

2006

CPR

View full text Add to dashboard Cite

With the epidemiology now well described, stroke has been uncovered as a frequent cause of neurological disease in children. Arterial ischemic stroke (AIS) is the most common type, affecting both neonates and older children. The number of associated risk factors is large with current efforts directed toward understanding the mechanisms by which they translate into a stroke. Advanced neuroimaging modalities are improving diagnostic accuracy while affording unique avenues to explore the pathophysiology of stroke and the response of the developing brain to injury. While acute interventions for pediatric stroke are in their infancy, the first randomized controlled clinical trials for the initial management and secondary prevention of pediatric stroke are poised to begin. Outcomes from childhood stroke are well defined though the accurate predictors required to guide treatment and rehabilitation remain elusive. We review the essential background, recent advances, and current clinical research issues pertaining to AIS in children.

show abstract

Acquired hemidystonia in childhood: A clinical and neuroradiological study of thirteen patients

Cited by 26 publications

References 29 publications

Patterns of EMG–EMG coherence in limb dystonia

Patterns of EMG–EMG coherence in limb dystonia

Complex movement disorders in primary antiphospholipid syndrome: A case report

Arterial Ischemic Stroke in Neonates and Children: Review and Current Issues

Contact Info

Product

Resources

About