Acquired haemophilia in recipients of depot thioxanthenes

Stewart, Andrew J.; Manson, Lynn; Dasani, H.; Beddall, Andrew; Collins, Peter William; Shima, Midori; Ludlam, C. A.

doi:10.1046/j.1365-2516.2000.00450.x

Cited by 9 publications

(7 citation statements)

References 12 publications

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“…The median age of the patients was 70 years (range 38–87 years). One patient had recently been started on a depot antipsychotic drug and was reported by Stewart et al (2000). No underlying cause was found in 14 patients (77%).…”

Section: Patient Clinical Characteristicsmentioning

confidence: 99%

A population based, unselected, consecutive cohort of patients with acquired haemophilia A

et al. 2003

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Summary Previous studies in acquired haemophilia A have reported on cohorts of patients referred to specialist centres or were retrospective surveys of specialist centre experience. This may have resulted in the literature representing a more severe group of patients than seen in routine haematological practice. We report on a consecutive, unselected cohort of all patients in south and west Wales who presented with acquired haemophilia A between 1996 and 2002. There were 18 patients, an incidence of 1·34/million/year. Compared with previously reported cohorts our patients were older, with a median age of 70 years, and less likely to have an underlying diagnosis (27%). The bleeding phenotype was less severe, with only 27% having life or limb threatening bleeds and 41% required no haemostatic treatment. One patient died of bleeding, but three died of complications related to immunosuppression. Response to immunosuppression was high compared with other series, with 88% of treated patients attaining an undetectable inhibitor and normal factor VIII level. These data suggest that previously reported cohorts may represent more severely affected patients and, whilst guidelines for treatment based on these assumptions may be valid for severely affected patients, they may not be universally applicable.

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Section: Patient Clinical Characteristicsmentioning

confidence: 99%

A population based, unselected, consecutive cohort of patients with acquired haemophilia A

et al. 2003

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“…In a multicentre retrospective study of non‐haemophilic patients with factor VIII inhibitor, Green and Lechner [3] observed more frequent spontaneous inhibitor disappearance in children. Total remission of the disease after corticosteroid therapy was also more frequent in children than in adults [5]. The dramatic course of the disease with quickly progressing bleeding into the soft tissue and muscles observed in our patient is typical in acquired haemophilia [5,15].…”

Section: Discussionmentioning

confidence: 67%

“…Total remission of the disease after corticosteroid therapy was also more frequent in children than in adults [5]. The dramatic course of the disease with quickly progressing bleeding into the soft tissue and muscles observed in our patient is typical in acquired haemophilia [5,15].…”

Section: Discussionmentioning

confidence: 67%

“…The appearance of the factor VIII inhibitor in non‐haemophilic patients is connected with severe, often life‐threatening bleeding in the soft tissue, muscles, retroperitoneal and retropharyngeal space and the central nervous system [1]. Autoantibodies to factor VIII occur in patients with autoimmune disorders, as well as benign lymphoproliferative diseases, leukaemia, lymphomas, asthma bronchiale and after administration of certain drugs [2–7]. They can appear during pregnancy and the postpartum period [8–10].…”

Section: Introductionmentioning

confidence: 99%

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Acquired factor VIII inhibitor in a non‐haemophilic boy

Klukowska¹,

Łaguna²,

Obitko-Pludowska³

et al. 2003

Haemophilia

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We describe the case of a previously healthy 8-year-old non-haemophilic boy who developed a factor VIII inhibitor of unknown origin. The symptoms of this disease were haemorrhages in the muscles of the right thigh, numerous bruises and a large haematoma of the right crus with subsequent tissue necrosis. Activated and non-activated prothrombin complex concentrates were administered in the therapy of the haemorrhages. To eliminate factor VIII inhibitor, the patient was treated first with prednisone, then immunoglobulin G and finally with a combination of prednisone and cycylophosphamide, without any effect. A total spontaneous remission was observed after 15 months from the beginning of the disease.

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“…Other studies reported the onset of acquired factor VIII inhibitors in two schizophrenic patients during treatment with depot thioxanthene preparations [32] and a case of acquired hemophilia associated with a phenothiazine derivative, which are well-known to induce autoantibodies such as antinuclear antibodies, antiphospholipid antibodies, and rheumatoid factors [33].…”

Section: Antipsychoticsmentioning

confidence: 99%

Anticoagulation and Psychotropic Medications

Bachawati

2010

Curr Psychiatry Rep

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Anticoagulants and psychotropic medications are commonly prescribed together. Thus, the potential for interaction exists. Whereas thrombolytics and heparins are implicated in few pharmacokinetic interactions, warfarin and platelet inhibitors have been implicated in various interactions with psychotropic medications. In this article, I review the various psychotropic drug classes' relationships to anticoagulants. In a field devoid of randomized, placebo-controlled trials, clinical vigilance is advised when managing patients on concomitant therapy.

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Acquired haemophilia in recipients of depot thioxanthenes

Abstract: We present two cases in which the occurrence of acquired haemophilia is associated with the use of depot preparations of the thioxanthenes zuclopenthixol and flupenthixol. These drugs have not previously been implicated in the aetiology of acquired haemophilia.

Cited by 9 publications

References 12 publications

A population based, unselected, consecutive cohort of patients with acquired haemophilia A

A population based, unselected, consecutive cohort of patients with acquired haemophilia A

Acquired factor VIII inhibitor in a non‐haemophilic boy

Anticoagulation and Psychotropic Medications

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