Acquired factor VIII inhibitor associated with chronic untreated hepatitis C

Shredi, Abdussalam; Elberson, Benjamin W.; Nawaa, Saif El; Ismail, Amr

doi:10.12746/swrccc.v6i23.465

Cited by 2 publications

(1 citation statement)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…14 Other conditions that are associated are skin disorders, such as pemphigus and epidermolysis bullosa, postpartum, infections (specifically hepatitis C, HIV, TB, urinary tract infection and influenza A), drugs (specifically factor VIII; antibiotics, such as penicillin, sulfonamides and chloramphenicol; anticonvulsants, such as phenytoin; and immunomodulators, such as fludarabine and interferon-alpha) and chronic graft versus host disease. [14][15][16][17][18] Idiopathic aetiology makes up the remaining 50% of cases. 13 As of this case report writing, there have also been three cases of SARS-CoV-2 infection associated with acquired haemophilia A being described in the literature.…”

Section: Discussionmentioning

confidence: 99%

Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection

et al. 2021

View full text Add to dashboard Cite

A 65-year-old man presented with symptoms of severe subcutaneous bleeding in his arm, which led to compartment syndrome requiring fasciotomy and massive blood transfusion protocol. Medical history was significant for history of autoimmune thyroid disease. Workup revealed elevated partial thromboplastin time, decreased factor VIII levels and elevated factor VIII inhibitor levels. He was worked up for causes of acquired haemophilia A and was found to have an elevated SARS-CoV-2 antibody level. Given his negative workup for other secondary aetiologies, we suspect that the cause of his haemophilia A was from his SARS-CoV-2 infection, which has been observed previously in various case reports.

show abstract

Section: Discussionmentioning

confidence: 99%

Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection

et al. 2021

View full text Add to dashboard Cite

show abstract

An Unusual Cause of Refractory Bleeding in Cirrhosis

Alvarado,

2024

ACG Case Rep J

View full text Add to dashboard Cite

Acquired hemophilia A (AHA) is a rare bleeding disorder caused by the development of antibodies against factor VIII. AHA has previously been reported in association with malignancy and autoimmune disorders, but rarely with liver disease. A prolonged activated partial thromboplastin time is the initial laboratory manifestation of this condition but may be challenging to interpret in the setting of abnormal markers of coagulation typically seen in cirrhosis. We present a case of AHA in a patient with decompensated cirrhosis resulting in refractory bleeding and highlight the complexities of interpreting abnormal coagulation factors in patients with cirrhosis.

show abstract

Acquired factor VIII inhibitor associated with chronic untreated hepatitis C

Abstract: AbstrAct

Cited by 2 publications

References 14 publications

Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection

Severe acquired haemophilia associated with asymptomatic SARS-CoV-2 infection

An Unusual Cause of Refractory Bleeding in Cirrhosis

Contact Info

Product

Resources

About