Acquired epileptiform aphasia: 44 years after diagnosis

Jokel, Regina; Meloff, Keith L.

doi:10.1016/j.ebr.2020.100388

Cited by 3 publications

(1 citation statement)

References 11 publications

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“…According to a retrospective study of Caraballo et al, at the end of a mean follow-up of 12 years, only eight out of 29 LKS cases recovered their language completely, while 21 cases still showed language deficits of different degrees [162]. Patients with LKS could need life-long support due to persisting and potentially debilitating deficits of verbal communication [188]. In a retrospective study involving 11 children, four cases showed no language problems after adolescence, four cases had moderate language problems, and three cases presented a severe language impairment > 10 years after the diagnosis [189].…”

Section: Outcomementioning

confidence: 99%

Continuous Spike–Waves during Slow Sleep Today: An Update

Posar,

Visconti

2024

Children

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In the context of childhood epilepsy, the concept of continuous spike–waves during slow sleep (CSWS) includes several childhood-onset heterogeneous conditions that share electroencephalograms (EEGs) characterized by a high frequency of paroxysmal abnormalities during sleep, which have negative effects on the cognitive development and behavior of the child. These negative effects may have the characteristics of a clear regression or of a slowdown in development. Seizures are very often present, but not constantly. The above makes it clear why CSWS have been included in epileptic encephalopathies, in which, by definition, frequent EEG paroxysmal abnormalities have an unfavorable impact on cognitive functions, including socio-communicative skills, causing autistic features, even regardless of the presence of clinically overt seizures. Although several decades have passed since the original descriptions of the electroclinical condition of CSWS, there are still many areas that are little-known and deserve to be further studied, including the EEG diagnostic criteria, the most effective electrophysiological parameter for monitoring the role of the thalamus in CSWS pathogenesis, its long-term evolution, the nosographic location of Landau–Kleffner syndrome, standardized neuropsychological and behavioral assessments, and pharmacological and non-pharmacological therapies.

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Section: Outcomementioning

confidence: 99%

Continuous Spike–Waves during Slow Sleep Today: An Update

Posar,

Visconti

2024

Children

View full text Add to dashboard Cite

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CSWS [Continuous Spike-Waves During Slow-Sleep] Today: An Update

Posar,

Visconti

2023

Preprint

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In the contest of childhood epilepsies, the concept of continuous spike-waves during slow sleep (CSWS) includes several childhood-onset heterogeneous conditions, sharing an electroencephalogram (EEG) characterized by a high frequency of paroxysmal abnormalities during sleep which are attributed negative effects on the cognitive development and behavior of the child. These negative effects may have the characteristics of a clear regression or of a slowdown in development. Seizures are very often present, but not constantly. The above makes it clear why CSWS have been included in epileptic encephalopathies, in which by definition the frequent EEG paroxysmal abnormalities have an unfavorable impact on the cognitive functions, including socio-communicative skills causing autistic features, even regardless of the presence of clinically overt seizures. Although several decades have passed since the original descriptions of the electroclinical condition of CSWS, there are still many areas that are little known and deserve to be further studied, including the EEG diagnostic criteria, the most effective electrophysiological parameter for monitoring the evolution, the role of the thalamus in the CSWS pathogenesis, the long-term evolution, the nosographic location of Landau-Kleffner syndrome, the standardized neuropsychological and behavioral assessment, the pharmacological and non-pharmacological therapies.

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How Encephalopathy Impacts Language Ability: A Scoping Review of the Linguistic Abilities of Adults with Developmental and Epileptic Encephalopathy

Papatheodorou,

Stavrakaki,

Koukoulioti

et al. 2024

Medicina

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Background and Objectives: Developmental and epileptic encephalopathy refers to a group of conditions where patients experience abnormal development due to various causes as well as frequent epileptiform discharges that ultimately contribute, in an independent and additive fashion, to cognitive and linguistic impairments. The language and cognition outcome of these patients in adulthood has been understudied. This paper aims to present a scoping review of linguistic abilities in adults with developmental and epileptic encephalopathy to determine the extent to which language outcomes in adulthood and their relation to cognitive outcomes have been studied. Design: Two online databases were searched and the methodological framework by Arksey & O’Malley (2005) was adopted. Results: Out of the 27 selected studies, only 13 exclusively examined adults, 15 were group studies, 5 were case studies and 7 were case series. A total of 9 out of the 15 group studies provided individual results for adults. Twenty-two studies included a follow-up examination. Twenty-three studies addressed the relationship between language and cognition. The selected studies indicate the presence of language impairments, which are nevertheless differentially manifested in the syndromes under investigation, whereas individual variability is also reported. Aspects of cognition seem to correlate with linguistic abilities. Conclusions: In sum, despite variability in linguistic abilities, language deficits constitute a significant aspect of the clinical profile of many adults with developmental and epileptic encephalopathy, a finding that should be taken into account for the treatment protocols of these individuals.

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Acquired epileptiform aphasia: 44 years after diagnosis

Cited by 3 publications

References 11 publications

Continuous Spike–Waves during Slow Sleep Today: An Update

Continuous Spike–Waves during Slow Sleep Today: An Update

CSWS [Continuous Spike-Waves During Slow-Sleep] Today: An Update

How Encephalopathy Impacts Language Ability: A Scoping Review of the Linguistic Abilities of Adults with Developmental and Epileptic Encephalopathy

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Acquired epileptiform aphasia: 44 years after diagnosis

Cited by 3 publications

References 11 publications

Continuous Spike–Waves during Slow Sleep Today: An Update

Continuous Spike–Waves during Slow Sleep Today: An Update

CSWS [Continuous Spike-Waves During Slow-Sleep] Today: An Update

How Encephalopathy Impacts Language Ability: A Scoping Review of the Linguistic Abilities of Adults with Developmental and Epileptic Encephalopathy

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Product

Resources

About

Acquired epileptiform aphasia: 44 years after diagnosis