Acquired Epidermal Hypermelanoses

Bahadoran, Philippe; Levine, Norman; Burk, Cynthia; Nordlund, James J.; Groysman, Vlada; Bangert, Scott; Fulk, Charles S.; Rubenzik, Randi; Urabe, Kazunori; Nakayama, Juichiro; Hori, Yoshiaki; Lamerson, Cindy L.; Breneman, Debra

doi:10.1002/9780470987100.ch50

Cited by 2 publications

(2 citation statements)

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“…246,247 Additionally, overproduction of melanin is implicated in a range of dermatological conditions including post inflammatory melanoderma and age spots. 248,249 Given the implications in melanoma and breadth of dermatological conditions in which melanin is involved, there is considerable interest in therapeutic strategies to modulate the production of melanin.…”

Section: Oxidoreductases (Ec 113 Ec 114)mentioning

confidence: 99%

“…Melanogenesis and its attenuation of common therapies has been observed in the clinic with melanin production being correlated with decreased survival rates of patients with stage III and IV melanoma . Evidence suggests that by decreasing melanin production in melanoma, the therapeutic efficacy of ionizing radiation and chemotherapy is improved. , Additionally, overproduction of melanin is implicated in a range of dermatological conditions including post inflammatory melanoderma and age spots. , Given the implications in melanoma and breadth of dermatological conditions in which melanin is involved, there is considerable interest in therapeutic strategies to modulate the production of melanin.…”

Section: Oxidoreductases (Ec 113 Ec 114)mentioning

confidence: 99%

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Targeting Metalloenzymes for Therapeutic Intervention

et al. 2018

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Metalloenzymes are central to a wide range of essential biological activities, including nucleic acid modification, protein degradation, and many others. The role of metalloenzymes in these processes also makes them central for the progression of many diseases and, as such, makes metalloenzymes attractive targets for therapeutic intervention. Increasing awareness of the role metalloenzymes play in disease and their importance as a class of targets has amplified interest in the development of new strategies to develop inhibitors and ultimately useful drugs. In this Review, we provide a broad overview of several drug discovery efforts focused on metalloenzymes and attempt to map out the current landscape of high-value metalloenzyme targets.

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