Abstract:Multidrug-Resistant (MDR) cancers mitigate the action of chemotherapeutics through drug efflux that occurs via ABC (ATP-Binding Cassette) transporters, including P-glycoprotein 1 (P-gp or ABCB1/MDR1). Because Toll-Like Receptor (TLR) agonist immunotherapies elicit abscopal anti-tumoral effects by modulating the activity of bystander tumor infiltrating immune cells, they not only circumvent the neutralizing effects of drug efflux, but could also work in synergy with this process. However, the effect of drug res… Show more
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