Acquired Disorders of Platelet Function

Hassan, Amy A.; Kroll, Michael H.

doi:10.1182/asheducation-2005.1.403

Cited by 53 publications

(47 citation statements)

References 38 publications

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“…There are numerous potential causes of bleeding in the critically ill patient, which are summarized in Table 1 and discussed in greater detail elsewhere [1][2][3][4][5][6]. Acquired hemophilia (AH) is a condition in which inhibiting antibodies develop against coagulation factors, most often from 6 to 8% even after the advent of effective treatments [9,10].…”

Section: Introductionmentioning

confidence: 99%

Acquired hemophilia: a rare but life-threatening potential cause of bleeding in the intensive care unit

2011

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Recognition of acquired hemophilia presents a clinical challenge, given the rarity of this condition, a general lack of familiarity with acquired hemophilia, and the potential for confusion with other more common causes of bleeding in the intensive care unit. Nevertheless, there are sentinel clinical and laboratory findings that should raise suspicion of this diagnosis. The treatment of acquired hemophilia is a multi-step, physiologically focused process aimed at controlling both active and recurrent bleeding. Therefore, prompt diagnosis is central to prognosis. Consultation with a hematologist may facilitate efficient diagnosis and management.

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Section: Introductionmentioning

confidence: 99%

Acquired hemophilia: a rare but life-threatening potential cause of bleeding in the intensive care unit

2011

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“…Clinically significant mucocutaneous bleeding is defined as any of the following: spontaneous or provoked bleeding from 2 or more distinct mucocutaneous sites; bleeding from a single site warranting blood transfusions; or bleeding from a single site on 3 or more separate occasions. 3,4 Bleeding scoring systems have shown promise in retrospectively predicting bleeding phenotype in type 1 VWD 5 and prospectively excluding mild bleeding disorders in patients presenting with bleeding symptoms or abnormal coagulation study results, 6 but they require further investigation and validation for broader clinical use.…”

Section: Abnormal Bleeding Symptomsmentioning

confidence: 99%

“…23 Routine hemostatic screening laboratories may likewise miss other platelet function defects. Consequently, in patients with mucocutaneous bleeding who do not have thrombocytopenia or VWD, platelet aggregometry should be considered as an initial test for assessing platelet function, 3 in addition to evaluation of a peripheral blood smear for abnormalities in platelet morphology that are specific to certain conditions (eg, gray platelet syndrome).…”

Section: Abnormal Bleeding Symptomsmentioning

confidence: 99%

“…19 Qualitative platelet disorders presenting in adults can be caused by medication (eg, aspirin and nonsteroidal anti-inflammatory drugs [NSAIDs]), uremia, cirrhosis, and myeloproliferative disorders. 3,20 Several inherited disorders of platelet function exist as well and are classified in various ways (by defective platelet function [eg, adhesion or aggregation] or platelet component [eg, receptors, granules, or membrane phospholipids]). 8,15 Although severe inherited disorders of platelet receptors (eg, Glanzmann thrombasthenia and Bernard-Soulier syndrome) and some platelet granule disorders typically present earlier in life, the majority of inherited platelet function disorders present during adulthood, often after hemostatic challenge.…”

Section: Abnormal Bleeding Symptomsmentioning

confidence: 99%

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Identification and Basic Management of Bleeding Disorders in Adults

Kruse‐Jarres

Singleton

Leissinger

2014

The Journal of the American Board of Family Medicine

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Adults with bleeding disorders may present to their family physician with minor bleeding symptoms or hematologic laboratory abnormalities discovered during evaluation for surgery or another purpose. Identifying the small proportion of adults who have an underlying bleeding disorder as the cause for such signs or symptoms may be challenging. In cases of asymptomatic hematologic laboratory abnormalities, the particular abnormality should narrow down the potentially affected hemostatic component(s), ideally streamlining subsequent investigation. In patients presenting with bleeding symptoms, a thorough history and physical examination are critical for first identifying bleeding as pathologic, then performing the appropriate diagnostic evaluation after excluding identifiable causes. Knowledge of the pathophysiologic processes contributing to impaired hemostasis in any given bleeding disorder ensures proper treatment and avoids therapies that are unnecessary or even contraindicated. Management is further determined by bleeding phenotype and, for invasive procedures, the anticipated risk for bleeding. Consultation with a hematologist may facilitate proper evaluation and treatment, particularly in adults with rare bleeding disorders or no identifiable cause for bleeding. This article reviews the diagnostic approach to hematologic laboratory abnormalities and abnormal bleeding in adults, as well as basic preventive care and hemostatic management of adults with bleeding disorders. (J Am Board Fam Med 2014;27:549 -564.)

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“…However, the detailed knowledge of the causal relationship leading to platelet function defects is necessary to choose the right management. Detailed advices for the management of different platelet disorders are given in several reviews on special aspects of platelet disorders [118][119][120][121].…”

Section: Management Of Platelet Disordersmentioning

confidence: 99%

Inherited and Acquired Disorders of Platelet Function

Jurk

Kehrel²

2007

Transfus Med Hemother

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Platelet function defects are caused by rare congenital or, more frequently, by acquired disorders. They may lead to bleeding or thrombotic tendencies despite of normal platelet counts. The corresponding symptoms are often quite heterogeneous. A disorder of platelet function is suspected on the basis of case and family history, physical examination and platelet function tests. The so far primary screen of platelet dysfunctions, the bleeding time, is neither very sensitive nor specific and depends very much on the skills of the person that performs the test. Therefore, other general and in addition more specialised laboratory tests have to be performed for diagnosing an isolated platelet abnormality or in most cases combined platelet function defects. An approach to diagnosing a platelet disorder is presented, which supports the high significance of flow cytometry in platelet function analysis. Furthermore, we like to elucidate that in most cases a platelet-mediated haemostatic disorder cannot be characterised by just a single function defect, but rather by a combination of platelet functional abnormalities. Detailed knowledge of the platelet disorder is necessary for adequate therapeutical management of the individual patient, including the control of the underlying disease in acquired disorders, transfusion of platelets and administration of haemostatic drugs.

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Acquired Disorders of Platelet Function

Cited by 53 publications

References 38 publications

Acquired hemophilia: a rare but life-threatening potential cause of bleeding in the intensive care unit

Acquired hemophilia: a rare but life-threatening potential cause of bleeding in the intensive care unit

Identification and Basic Management of Bleeding Disorders in Adults

Inherited and Acquired Disorders of Platelet Function

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