Acquired Disorders of Platelet Function

Konkle, Barbara A.

doi:10.1182/asheducation-2011.1.391

Cited by 91 publications

(51 citation statements)

References 36 publications

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“…dilution of platelet numbers resulting from transfusion of platelet-poor blood can cause this condition [15]. Disorders of platelet adhesion, idiopathic alpha, disorders of platelet granules [16] or acquired platelet function disorders including medication and chemicals, chronic kidney disease and myeloproliferative disorders cause platelet function disorders that may be inherited [17]. Emergent plasma exchange is the cornerstone of TTP treatment [18], while short "pulses" of dexamethasone have been found to be very effective in initial management of immune thrombocytopenia [19].…”

Section: Determination Of Hematological Parametersmentioning

confidence: 99%

Determination of Hematological Effects of Methanolic Leaf Extract of S. incanum in Normal Mice

Muriithi¹,

Maina²,

Mugendi³

2015

Pharm Anal Acta

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Medicinal plants and herbs have been used for ages for the purposes of enhancing and maintaining health and organic resistance against body infection. This is due to their ready availability and arguably efficacious state, therefore offering an alternative remedy in enhancing hematological parameters. Various chemical constituents of Solanum incanum (Linn) are believed to possess therapeutic effects on hematological parameters, but these effects have not been subjected to systematic scientific studies to substantiate and ascertain the therapeutic claims made regarding their clinical utility. This study investigates the hematological effects of S. incanum (Linn) in normal mice. The experimental mice groups were treated with methanolic seed extracts of S. incanum (Linn) at concentrations of 50 mg/kg and 100 mg/kg orally once per two days for a period of fourteen days. Hematological parameters and indices of unclotted blood were determined using standard protocols. Phytochemicals were determined using standard protocols. Seven and fourteen days after administration of methanolic seed extracts of S. incanum at the dose level of 50 mg/kgbw, there was significant increase in erythrocytes, hemoglobin and hematocrit counts while the dose level of 100 mg/kgbw caused significant increase in hematocrit count fourteen days after administration of the extract. There was a significant increase in levels of total white blood cells, neutrophils and basophil counts seven and fourteen days after administration of the methanolic seed extract of S. incanum at the dose level of 50 mg/kgbw. The dose level of 50 mg/kgbw of methanolic seed extract of S. incanum caused a significant increase in platelet, plateletcrit, MPV, and PDW profiles after seven days. In addition phytochemical screening results showed that the seed extract of S. incanum (Linn) had phytochemicals associated with erythropoietin promoting activity, immunostimulatory activities and thrombopoietin stimulation.

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Section: Determination Of Hematological Parametersmentioning

confidence: 99%

Determination of Hematological Effects of Methanolic Leaf Extract of S. incanum in Normal Mice

Muriithi¹,

Maina²,

Mugendi³

2015

Pharm Anal Acta

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“…There are two isoforms of COXs: COX-1 and COX-2. COX-1 is expressed constitutively in most tissues; COX-2 is induced by stimuli such as bacterial lipopolysaccharide (LPS) and cytokines [30][31][32]. 5-LOX catalyzing AA pathway results in the generation of leukotrienes (LTs) which are also actively involved in inflammatory diseases [33].…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inhibition of Phospholipase A2/Arachidonic Acid Pathway

Xie

et al. 2015

Inflammation

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Glycyrrhiza glabra (licorice) has been known to possess various pharmacological properties including anti-inflammatory, antioxidants, antiviral, and hepatoprotective activities. Magnesium isoglycyrrhizinate (MgIG), a magnesium salt of 18-α glycyrrhizic acid stereoisomer, is clinically used for the treatment of inflammatory liver diseases. However, the mechanism by which MgIG exerts its anti-inflammatory effects remains unknown. In the present study, we investigated the inhibitory potential of MgIG in phospholipase A2 (PLA2)/arachidonic acid (AA) pathway and release of the pathway-generated inflammatory lipid mediators in RAW264.7 macrophages. Results revealed that MgIG suppressed LPS-induced activation of PLA2 and production of AA metabolites such as prostaglandin E2 (PGE2), prostacyclin (PGI2), thromboxane 2 (TXB2), and leukotrienes (LTB4) in macrophages. Furthermore, LPS-induced AA-metabolizing enzymes including COX-2, COX-1, 5-LOX, TXB synthase, and PGI2 synthase were significantly inhibited by MgIG. Taken together, our data suggest that modulation of cyclooxygenase (COXs) and 5-lipoxygenase (LOX) pathways in AA metabolism could be a novel mechanism for the anti-inflammatory effects of MgIG.

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“…5 Different medications responsible for platelet interference are nitrates, beta-lactam antibiotics, beta-blockers, nitrates, tricyclic antidepressants; etc. 6 Heparin exposure can also lead to life-threatening thrombocytopenia. 7 Immune-mediated disorders (e.g.…”

Section: Thrombocytopeniamentioning

confidence: 99%

A randomized, double-blind, placebo-controlled, proof of concept study to assess the safety and efficacy of Carica papaya and Tinospora cordifolia leaf extract (Thrombobliss) in subjects undergoing chemotherapy treatment and subjects with systemic microbial infection and subsequent reduction in platelet count

Babu

Kubavat

Poulose³

et al. 2017

Int J Clin Trials

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Background: Thrombocytopenia is defined as persistent decrease in the number of blood platelets. Thrombocytopenia usually serves as symptom for identifying hematologic malignancies, infectious diseases, autoimmune disorders and as common side effect of about 200 different disease types. There was neither a specific treatment available for thrombocytopenia, nor to increase the platelet count leading to mortality. Current methods are less effective and have their limitations. This study was conducted to prove that Carica papaya and Tinospora cordifolia leaf extract can increase the platelet count in study subjects with dengue, other microbial infections. Methods: Totally 250 patients were randomized, subjects within inclusion criteria and exclusion criteria were randomly assigned, in a 1:1 ratio, to receive orally thrombobliss in a dose of 5 ml syrup twice daily or placebo for five consecutive days. Platelet count was monitored every day. Results: The result showed that there is increase in the platelet count from day 2 in median platelet data and more evident after 72 hours seen in both mean and median platelet count. Even in the cancer patients undergoing chemotherapy, there has been significant increase in platelet count. The statistical analysis of the data showed that there is a significant increase in platelet count and is statistical significant p<0.05. Conclusions: This study showed that novel combination of Carica papaya and Tinospora cordifolia leaf extract effectively increases platelet count and can be used to treat thrombocytopenia. It is also evident that this combination is safe and effective in treating thrombocytopenia patients due to dengue and other microbial infection.

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Acquired Disorders of Platelet Function

Cited by 91 publications

References 36 publications

Determination of Hematological Effects of Methanolic Leaf Extract of S. incanum in Normal Mice

Determination of Hematological Effects of Methanolic Leaf Extract of S. incanum in Normal Mice

Anti-inflammatory Activity of Magnesium Isoglycyrrhizinate Through Inhibition of Phospholipase A2/Arachidonic Acid Pathway

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