Acquired Cystic Disease of the Kidney and Renal Cell Carcinoma on Long Term Hemodialysis

Konishi, Fumio; Mukawa, A; Kitada, Hirohisa

doi:10.1111/j.1440-1827.1980.tb00977.x

Cited by 16 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, we failed to demonstrate significant correla tion between ARCD and the chronological date of death. In addition, this discrepancy may be related to the larger and more heterogeneous (with and without replacement therapy) patient population included in the present study, compared to most previous reports which in cluded only patients receiving hemodialysis [3,9,14,15,17,18]. In the present report, ARCD was also noted in ESRD patients who were not receiving dialysis or re ceived it for less than 6 months prior to death.…”

Section: Discussioncontrasting

confidence: 43%

“…ARCD was previously reported in patients with mild and advanced renal fail ure prior to institution of dialysis [3,7,9,12]. In recent years, most investigators found a statistically significant association between ARCD and duration of dialysis [3,14,15,18]. While we noted an incidence of 58% ARCD in our ESRD population, we did not document a strong association between the incidence of cystic transforma tion and duration of dialysis (p = 0.06), even if patients with duration of dialysis less than 6 months were ex cluded (p = 0.07).…”

Section: Discussionmentioning

confidence: 96%

“…Renal Ishikawa and Shinoda [17] reported the incidence of ARCD among patients undergoing hemodialysis for less than 3 years to be 43.5%, and 78.3% in patients on replacement therapy for a period exceeding 3 years. The overall incidence of renal tumorous degeneration (ade noma and carcinoma) in patients with end-stage renal disease (ESRD) is estimated at 9% [6,[18][19][20][21][22], The occurrence of renal tumors is enhanced when ARCD is present; the reported prevalence is 19-25% [9], Malig nant transformation of these tumors is reported to be 4% [1]. Bretan et al [9] suggested the 'pathologic continuum' from simple cyst to epithelial hyperplasia to tumorous degeneration.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Acquired Renal Cystic Disease in End-Stage Renal Disease: An Autopsy Study of 155 Cases

Miller¹,

Soffer²,

Nassar³

et al. 1989

Am J Nephrol

View full text Add to dashboard Cite

Autopsy reports on 155 successive end-stage renal disease (ESRD) patients and 147 control patients without ESRD, matched for age, race and gender, were collected. Cystic transformation of the kidneys was noted in 58% of the ESRD patients and 13.6% of the control patients. There were 25 ESRD patients with renal adenoma and 3 with renal cell carcinoma. The single best predictor of cystic transformation or tumorous degeneration was patient’s age. A statistically significant association between cystic transformation and gender, as well as the cause of ESRD, was also found. In contrast to previous reports we were unable to document a strong association between the incidence of either cystic transformation or tumorous degeneration with the duration of dialysis, nor did these two parameters correlate with mode of dialysis. We suggest that cystic transformation of the kidneys in ESRD is related to age and renal failure per se, is not strongly associated with duration of dialysis and is independent of mode of dialysis. Concomitant tumorous degeneration was frequent, but this was usually an incidental autopsy finding. Renal malignancy was uncommon and metastases were absent.

show abstract

Section: Discussioncontrasting

confidence: 43%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Acquired Renal Cystic Disease in End-Stage Renal Disease: An Autopsy Study of 155 Cases

Miller¹,

Soffer²,

Nassar³

et al. 1989

Am J Nephrol

View full text Add to dashboard Cite

show abstract

“…A high incidence of neoplastic transformation has been noted in the kidneys with ACD in dialysis patients [2,6,8,9,12,13]. In addition, various neoplasms are known to occur with increased frequency in transplant recipients [14], I of our transplant recipients was found to have multifocal clear cell carcinoma of his cystic kidneys.…”

Section: Discussionmentioning

confidence: 89%

Acquired Renal Cystic Disease in Renal Transplant Recipients

Vaziri

Darwish

Martin

et al. 1984

Nephron

View full text Add to dashboard Cite

End-stage kidneys are known to undergo cystic transformation in patients treated with long-term hemodialysis. Little has been published, however, on the occurrence of acquired renal cystic disease (ACD) in renal transplant recipients. The available clinical and histopathological data were gathered on 22 renal transplant recipients who had undergone either necropsy or nephrectomy. None of our patients exhibited cystic changes in their donor kidneys. However, 11 patients (50%) had ACD of the native kidneys while the remaining patients lacked ACD. The duration of dialysis prior to transplantation was significantly longer and the life of the functional transplant kidney was significantly shorter in the ACD group as compared to the noncystic group. The combined duration of ESRD (dialysis + transplantation), however, was comparable in the two groups. It thus appears that the presence of a functioning renal allograft somehow retards the evolution of cystic changes in the diseased native kidneys. 1 of the patients in the ACD group exhibited superimposed multifocal clear cell carcinoma of the affected kidney, while none of the patients in the noncystic group exhibited renal neoplasm.

show abstract

“…Die ARCD ist ein hä ufig vertretenes Krankheitsbild bei Patienten mit terminaler Niereninsuffizienz mit einer Inzidenzrate, die zwischen 50 und 95 % angegeben wird [9,10]. Hierbei handelt es sich um bilaterale zystische Deformationen von sekundä ren Schrumpfnieren infolge einer chronischen Dialysebehandlung.…”

Section: Diskussionunclassified

Die klinische Bedeutung des Nierenzellkarzinoms beim dialysepflichtigen Patienten im Vergleich zu Nieren- transplantatempfängern

et al. 1997

View full text Add to dashboard Cite

The clinical relevance of de novo Renal Cell Cancer was compared in chronic hemodialysis patients and renal allograft recipients. Clinical course of these patients was followed for 15 years. 21 of 788 patients who underwent radical nephrectomy were suffering from renal insufficiency at the time of surgery. Evaluated data included clinical symptoms; tumor histology and clinical course. 19 patients received chronic hemodialysis treatment. 7 patients demonstrated stable function of the allograft. 92% of patients receiving hemodialysis treatment did not show metastasis and none died of renal cell carcinoma. On the contrary, 71% of patients who underwent renal transplantation showed advanced tumor disease or metastasis. 3 patients have died of RCC. Aggressive tumor growth of RCC requires close follow up in patients who received a renal allograft.

show abstract

Acquired Cystic Disease of the Kidney and Renal Cell Carcinoma on Long Term Hemodialysis

Cited by 16 publications

References 10 publications

Acquired Renal Cystic Disease in End-Stage Renal Disease: An Autopsy Study of 155 Cases

Acquired Renal Cystic Disease in End-Stage Renal Disease: An Autopsy Study of 155 Cases

Acquired Renal Cystic Disease in Renal Transplant Recipients

Die klinische Bedeutung des Nierenzellkarzinoms beim dialysepflichtigen Patienten im Vergleich zu Nieren- transplantatempfängern

Contact Info

Product

Resources

About