Acquired cystic disease–associated renal cell carcinoma with sarcomatoid change and rhabdoid features

Kuroda, Naoto; Tamura, Masato; Hamaguchi, Nobumasa; Mikami, Shuji; Pan, Chin Chen; Brunelli, Matteo; Martignoni, Guido; Hes, Ondřej; Michal, Michal; Lee, Gang Hong

doi:10.1016/j.anndiagpath.2010.07.008

Cited by 43 publications

(45 citation statements)

References 14 publications

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“…These results suggest that the candidate tumor suppressor genes involving dedifferentiation in RCC such as sarcomatoid differentiation or rhabdoid change may be located on chromosomes 9, 14 and 15 [18,31]. In RCC with rhabdoid features, the same genetic alterations including chromosome 3p loss and VHL gene mutation were observed in both clear cell RCC and rhabdoid components [21].…”

Section: Molecular Genetic Findingsmentioning

confidence: 87%

“…Therefore, it may be interesting to study the expression of p53, AEG-1 and MDM2 in RCC with rhabdoid features. Although combined loss of BAP1 and PBRM1 seems to be closely associated with rhabdoid phenotype, the identification of new candidate tumor suppressor genes which may be located on chromosomes 9, 14 or 16 potentially opens up future targeted therapeutic strategies [18,31,32]. The pathological significance of cohesive rhabdoid morphology in RCC with ALK gene rearrangement remains unknown [19].…”

Section: Future Perspectivesmentioning

confidence: 99%

“…Spectral karyotype analysis of primary cell culture of clear cell RCC established from skin metastasis showed hypertriploid karyotype: <3n>, -Y, +2, +der(3)t(3;5), der(5)t(5;6)x2, del(6p)x2, +6, +7x2, +iso(8)(q10)x2, +8, -9, +12, -13, -14, -15, +17, +der (19) [11,18]. These results suggest that the candidate tumor suppressor genes involving dedifferentiation in RCC such as sarcomatoid differentiation or rhabdoid change may be located on chromosomes 9, 14 and 15 [18,31].…”

Section: Molecular Genetic Findingsmentioning

confidence: 99%

“…Metastasis occurs in up to 70% of cases, and distant metastasis can occur in lung, bone, soft tissue, liver, skin, adrenal gland and diaphragm [4-10, 13, 14, 16-18, 25, 31]. Metastases to lymph nodes occur in approximately 20% of cases [7,10,16,18,25].…”

Section: Prognosismentioning

confidence: 99%

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Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects

Karashima¹,

Inoue²,

Kasajima³

et al. 2015

pjp

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Section: Molecular Genetic Findingsmentioning

confidence: 87%

Section: Future Perspectivesmentioning

confidence: 99%

Section: Molecular Genetic Findingsmentioning

confidence: 99%

Section: Prognosismentioning

confidence: 99%

See 2 more Smart Citations

Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects

Karashima¹,

Inoue²,

Kasajima³

et al. 2015

pjp

Self Cite

View full text Add to dashboard Cite

“…3 On the other hand, cystic Wilms' tumor, tubulocystic renal cell carcinoma, acquired cystic disease associated renal cell carcinoma, and cystic synovial sarcoma are more aggressive with regard to their metastatic potential. [12][13][14][15][16][17] Therefore, diagnosis of these lesions is important for determination of prognosis and to guide surveillance imaging strategies.…”

Section: Discussionmentioning

confidence: 99%

Cystic Nephroma/Mixed Epithelial Stromal Tumor

et al. 2014

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Cystic nephroma (CN) is a rare, benign, renal neoplasm composed of epithelial and stromal elements. Only about 200 cases have been reported since 1892 and recurrence has rarely been observed. We report a 32-year-old Hispanic woman, with a history of a right, complex cystic, renal mass treated by robotic decortication 2 years ago, who presented with flank pain, hematuria, and recurrent urinary tract infection. A magnetic resonance imaging study showed a 3.4-cm multicystic lesion with thickened septa and enhancement at the right kidney. The partial nephrectomy specimen revealed a well-circumscribed, multicystic tumor abutting the renal pelvis, with thick septa and smooth walls, filled with clear fluid. Microscopic examination showed variably sized cysts lined by cuboidal epithelium with focal hobnailing, without significant cytologic atypia and mitosis. The epithelial lining was positive for CK19, high molecular weight cytokeratin, and α-methylacyl-CoA racemase suggesting a primitive tubular epithelial phenotype. Primitive glomeruli-like structures were also present. The ovarian-like stroma was condensed around the cysts and was variably cellular with areas of muscle differentiation and thick-walled vessels. The stroma was positive for desmin, estrogen receptor, progesterone receptor, and CD10. We suggest that CN represents a variable mixture of epithelial and stromal elements, immature glomerular, tubular, muscle, and vascular elements, which may be present in variable proportions creating a spectrum of lesions previously described as CN and mixed epithelial and stromal tumors (MEST). This case emphasizes that CN/MEST clinically/radiologically mimics other cystic renal neoplasms, especially cystic renal cell carcinoma and tubulocystic carcinoma, necessitating histopathological examination and immunohistochemial studies for definitive diagnosis. Additionally, CN has the tendency to recur when not completely excised initially.

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New entities, new technologies, new findings: A review of the cytologic features of recently established subtypes of renal cell carcinoma

Robila

Kraft

Smith

2019

Cancer Cytopathology

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Several new renal tumor types with distinctive pathologic, epidemiologic, and genetic signatures have recently been adopted in the fourth edition of the World Health Organization classification. In succeeding years, the cytologic features of most of these new types have been described, adding to the trend of increasing diagnostic accuracy for most common renal cell carcinoma subtypes and the important diagnostic role of cytologic sampling in the management and personalization of therapy. The current article reviews the cytologic findings from these recently established renal cell carcinoma subtypes. Emphasis is placed on cytologic diagnostic clues, confirmatory ancillary testing, salient differential diagnoses, and challenges that can be encountered in an attempt to render accurate interpretations in small samples.

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Acquired cystic disease–associated renal cell carcinoma with sarcomatoid change and rhabdoid features

Cited by 43 publications

References 14 publications

Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects

Review of renal cell carcinoma with rhabdoid features with focus on clinical and pathobiological aspects

Cystic Nephroma/Mixed Epithelial Stromal Tumor

New entities, new technologies, new findings: A review of the cytologic features of recently established subtypes of renal cell carcinoma

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