Acquired Cutis Laxa: Case Report and Review of Disorders of Elastolysis

Abstract

A 10-year-old boy developed cutis laxa while receiving isoniazid therapy; no systemic manifestations occurred. There are several well-documented cases of acquired cutis laxa. We propose a classification of the elastolysis syndromes, including inherited, neonatal, and acquired forms of cutis laxa.

Generalized Cutis Laxa Associated with Heavy Chain Deposition Disease

“…18 In type I or generalized acquired elastolysis, the skin laxity often begins on the face and neck, with progressive development of generalized skin laxity in a cephalocaudad direction. 1,13 Rare cases may be localized, such as to the face, the ears, or the fingers and toes. 3,[19][20][21][22] Approximately half of acquired cases of cutis laxa are preceded by skin lesions, which may present with various morphologies, including erythematous plaques, edema, bullae, drug eruptions, erythema multiforme, urticaria, eczema, allergic reactions, or a dermatitis herpetiformis-like eruption.…”

“…1,4,6 Cutis laxa also has inherited forms, including both autosomal recessive and dominant forms, and a transient neonatal form. All types show similar clinical and histologic changes.…”

“…C utis laxa, also known as generalized elastolysis, is a heterogeneous group of inherited and acquired disorders characterized clinically by loose skin and histologically by altered elastic tissue. 1 The clinical presentation consists of localized or large areas of skin laxity associated with decreased elastic recoil on stretching. [1][2][3][4][5] The skin may appear loose and redundant, resulting in an appearance older than the patient's actual age.…”

“…1 The clinical presentation consists of localized or large areas of skin laxity associated with decreased elastic recoil on stretching. [1][2][3][4][5] The skin may appear loose and redundant, resulting in an appearance older than the patient's actual age. [4][5][6] Affected patients commonly have abnormalities in multiple organ systems, including cutaneous, pulmonary, cardiovascular, gastrointestinal, and urogenital systems.…”

Unilaterale Blepharochalasis mit läsionalen IgA-Ablagerungen

“…Diesen stehen die erworbenen Cutis-laxa-Formen gegenüber, die lokalisiert oder generalisiert auftreten können. Die erworbene Cutis laxa kann sich spontan [17] oder nach einer entzündlichen Hautkrankheit, wie beispielsweise dem Sweet-Syndrom, entwickeln [10].Auch nach Medikamenteneinnahme [8], im Rahmen von Autoimmunerkrankungen [13,16] oder beim nephrotischen Syndrom [18] wurden lokalisierte Elastolysen in Form einer Cutis laxa beschrieben.…”