Acquired cutis laxa associated with chronic urticaria

Case of acquired cutis laxa with preceding urticarial eruption treated by diphenyl sulfone

“…Thus, acquired CL might have been triggered by urticarial eruption. In three cases,2, 3, 4 a biopsy was performed on an urticarial lesion, and revealed the presence of neutrophils, while the elastic fibers were thin and fragmented. In our case, neutrophils adhered to elastic fibers.…”

Generalized Cutis Laxa Associated with Heavy Chain Deposition Disease

“…7,23,28,29 The remaining elastic fibers are markedly fragmented, granular or clumped, and of variable orientation and diameter. 3,4,6,7,9,14,23,28,29 The preelastic fibers, oxytalan and elaunin, are undetectable, and the microfibrillar component of elastic fibers is reduced. 30,31 Electron microscopy confirms the degenerative changes in the elastin fibers.…”

“…3,[19][20][21][22] Approximately half of acquired cases of cutis laxa are preceded by skin lesions, which may present with various morphologies, including erythematous plaques, edema, bullae, drug eruptions, erythema multiforme, urticaria, eczema, allergic reactions, or a dermatitis herpetiformis-like eruption. [1][2][3]5,7,11,14,23 Localized areas of cutis laxa may develop in sarcoidosis, syphilis, pseudoxanthoma elasticum, neurofibromatosis, and varicose veins. 3,24 Most, if not all, patients with onset after 20 years of age have manifested systemic involvement, which may develop as a result of elastic tissue damage in organs in which the elastic fibers are of functional importance.…”

Generalized elastolysis following nephrogenic fibrosing dermopathy

“…Focal loss of elastic tissue in the mid-reticular dermis causing patches and plaques of finely wrinkled skin characterize mid-dermal elastolysis. 7,8 The condition may follow urticaria, 9 granuloma annulare, 10 and exposure to ultraviolet radiation, 11 suggesting a possible postinflammatory elastolytic process. Curiously, this case represents a primarily infiltrative disease (NFD), not an inflammatory condition, resolving in a generalized elastolysis.…”