Acquired Bleeding Disorders

Hurwitz, Alisheba; Massone, Richard; Lopez, Bernard L.

doi:10.1016/j.hoc.2017.08.012

Cited by 14 publications

(4 citation statements)

References 107 publications

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“…quantitative disorder, thrombocytopenia) or platelets function (i.e. qualitative disorder, thrombocytopathia) may affect haemostasis and induce prolonged bleeding of the skin and mucous membranes (Hurwitz et al., ). Thrombocytopenia is defined as a platelet count ≤ 100,000/μl and is due to decreased production (e.g.…”

Section: Introductionmentioning

confidence: 99%

“…Bleeding disorders can be acquired, such as those induced by medication, liver disease and autoimmune disease, for example immune thrombocytopenia (ITP) or infection as in human immunodeficiency virus (HIV) infection (Hurwitz, Massone, & Lopez, ). Or it could be inherited such as those affecting the vascular lining (e.g.…”

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

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World Workshop on Oral Medicine VII: Platelet count and platelet transfusion for invasive dental procedures in thrombocytopenic patients: A systematic review

et al. 2019

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Objectives To evaluate the evidence for a 50,000/μl platelet count threshold for platelet transfusion for invasive dental procedures in thrombocytopenic patients. Subjects and Methods We searched in MEDLINE/PubMed, EMBASE, the Cochrane Library (Wiley) and Scopus from 1960 through April 2018 for studies on patients with quantitative platelet disorders not related to medical co‐morbidities or medications and undergoing invasive dental procedures. Two reviewers conducted assessments independently. Results We found a total of 176 non‐duplicate articles, of which 9 cohort studies met our inclusion criteria. The incidence of postoperative bleeding in thrombocytopenic patients was low (4.9%), and we found no difference in bleeding incidence between patients who had platelet transfusion and those who did not. There was no difference in the mean platelet count for patients with and without bleeding. Different modalities are now available to prevent and control bleeding, which may reduce the need for platelet transfusion. Conclusions There is no evidence to support the long‐standing dogma of a need for a platelet count ≥ 50,000/μl for safe invasive dental procedures. Platelet transfusion effectiveness for haemostasis support could not be determined based on available data. Local measures and antifibrinolytics are the mainstay for the prevention and management of bleeding.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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World Workshop on Oral Medicine VII: Platelet count and platelet transfusion for invasive dental procedures in thrombocytopenic patients: A systematic review

et al. 2019

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“…The clinical course is variable, ranging from mild conditions to clinically significant, life-threatening bleeds [4]. Bleeding is limited mainly to the mucosa, skin or muscle; by contrast, bleeding caused by congenital hemophilia tends to mainly involve the joints [15].…”

Section: Introductionmentioning

confidence: 99%

First Case of Acquired Hemophilia B in a Patient with HIV Infection: Case Report and Literature Review

Páramo

Olivera²,

Noreña³

et al. 2019

Cureus

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Acquired hemophilia B is a rare bleeding disorder in which circulating specific antibodies inhibit the coagulation factors. Usually, it is associated with autoimmune diseases, malignancy and some infections such as hepatitis B (HBV) and C (HCV) viruses. The association with the human immunodeficiency virus (HIV) is rare. We present the first case of hemophilia B acquired in a patient with HIV. A 36-year-old woman with a history of HIV infection stage 3 acquired immunodeficiency syndrome (AIDS) (CDC 2014) and glomerulopathy secondary to HIV. She consulted for subacute non-dysenteric diarrhea. During her hospitalization, bacteremia by methicillin-sensitive Staphylococcus aureus ( S.au reus) was documented, requiring hemodialysis catheter replacement with profuse bleeding during the procedure. The coagulation tests showed prolonged activated partial thromboplastin time (aPTT), normal prothrombin time (PT), mixing test with Rosner index: 8.8%, negative lupus anticoagulant, and specific tests for normal factor VIII and XI. The activity of factor IX was <50% and the inhibitor was increased, which confirms the diagnosis of hemophilia B. Acquired hemophilia B in a patient with HIV infection is not a frequent association; it should be suspected in the context of bleeding with prolonged aPTT.

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Disorders of haemostasis

Hampton¹

2022

Pathy's Principles and Practice of Geriatric Medicine

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Acquired Bleeding Disorders

Cited by 14 publications

References 107 publications

World Workshop on Oral Medicine VII: Platelet count and platelet transfusion for invasive dental procedures in thrombocytopenic patients: A systematic review

World Workshop on Oral Medicine VII: Platelet count and platelet transfusion for invasive dental procedures in thrombocytopenic patients: A systematic review

First Case of Acquired Hemophilia B in a Patient with HIV Infection: Case Report and Literature Review

Disorders of haemostasis

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