Acquired Blaschkolinear dermatoses

Grosshans, É

doi:10.1002/(sici)1096-8628(19990806)85:4<334::aid-ajmg4>3.0.co;2-f

Cited by 69 publications

(16 citation statements)

References 12 publications

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“…3 The differential diagnosis of LPP includes conditions such as lichen striatus, erythema dyschromicum perstans, incontinentia pigmenti, linear and whorled nevoid hypermelanosis, occupational lesions of classical lichen planus can also occur over the Blaschko lines. 7 The majority of LPP lesions are usually distributed in areas exposed to the sun; trunk lesions, such as those observed in the present case, are rarely observed. 8 Both topical and oral treatments for LPP have been used with varying results, including topical steroids, keratolytics, tacrolimus, griseofulvin, prednisone, etretinate and chloroquine.…”

Section: Commentmentioning

confidence: 57%

Lichen Planus Pigmentosus with Blaschkoid Distribution

Alonso-Corral¹,

Garrido‐Colmenero²,

Almódovar-Real³

et al. 2016

SQUMJ

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interesting medical image A 57-year-old woman presented at a dermatology unit in Granada, Spain, in 2015 with a two-month history of slightly pruritic brown-coloured macular lesions on the trunk and right arm. She was not taking any medications or using cosmetics and had not been exposed to the sun before the onset of the rash. On examination, clearly defined hyperpigmented brown macules were seen on the right submammary region, right hemithorax, right abdomen and right buttock [ Figure 1] with an S-shaped appearance, compatible with the pattern of Blaschko lines. Tests for hepatitis B and hepatitis C were negative. A histological examination showed rich lymphocytic infiltrate and melanin incontinence with slight epidermal atrophy and lichenoid reaction with hypergranulosis [ Figure 2]. Considering these features, a diagnosis of lichen planus pigmentosus (LPP) with Blaschkoid distribution was proposed. The patient was prescribed topical clobetasol propionate for four weeks. The lesions responded well to the treatment, with significant pigment reduction and improvement of the associated pruritus. CommentVarious triggering factors, ranging from viral infections and vaccinations to trauma, have been implicated in the aetiology of lichen planus.1 A rare variant of lichen planus, LPP is distinguished by hyperpigmented macules or papules. The histological characteristics of LPP include epidermal atrophy, vacuolar degeneration of the basal cell layer and rich dermal lichenoid infiltrate.2 Kanwar et al. suggested that LPP may represent a lichenoid reaction to an unknown agent or stimuli, with regards to the histological concordance between LPP and lichen planus.3 The differential diagnosis of LPP includes conditions such as lichen striatus, erythema dyschromicum perstans, incontinentia pigmenti, linear and whorled nevoid hypermelanosis, occupational Sultan Qaboos University Med J, August 2016, Vol. 16, Iss. 3, pp. e383-384,

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Section: Commentmentioning

confidence: 57%

Lichen Planus Pigmentosus with Blaschkoid Distribution

Alonso-Corral¹,

Garrido‐Colmenero²,

Almódovar-Real³

et al. 2016

SQUMJ

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“…Lichen striatus is a cutaneous disease of childhood, presenting as a self-limited, usually asymptomatic, linear rash with an average age of onset between 3 and 4 years 17,18 . Lichen striatus usually appears as an eruption of small erythematous papules that coalesce into a solitary, usually unilateral, narrow band on an extremity over the course of several days to weeks 17,18 . The disease typically resolves spontaneously and does not require treatment, and relapse is unusual 18 .…”

Section: Discussionmentioning

confidence: 99%

“…Adult blaschkitis is a relapsing, linear papulovesicular inflammatory dermatitis that also manifests along the lines of Blaschko 8,17,19 . Alternatively known as acquired relapsing self-healing blaschkitis, adult blaschkitis was first described in 1990 by Grosshans and Marot as a self-limiting eruption of papules, vesicles, and plaques, usually with accompanying pruritus 20 .…”

Section: Discussionmentioning

confidence: 99%

Interface dermatitis along Blaschko's lines

Johnson

Walker

Galloway³

et al. 2014

J Cutan Pathol

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Linear dermatoses are fascinating entities that likely reflect embryologically derived cutaneous mosaicism, even when they occur after childhood. Adult blaschkitis is a rare, relapsing inflammatory dermatitis that most often presents in middle age. It presents clinically as a pruritic eruption of linear papules, vesicles and plaques, and is most commonly found to have features of spongiotic dermatitis on pathology. However, the clinical and histopathologic presentation of lichen striatus in adults may be similar to those of adult blaschkitis. A case in which 'blaschkitis' was suspected clinically is presented, in which the biopsy showed non-characteristic microscopic features resembling erythema multiforme--a finding rarely reported in the literature to date. We present this case and a brief review of the most commonly acquired linear eruptions following Blaschko's lines with the goal of expanding the histopathologic findings that may be encountered in adult blaschkitis. Moreover, the clinical and histopathologic overlap between the entities of blaschkitis and lichen striatus is explored, acknowledging that these entities may exist on a clinicopathologic spectrum. In the diagnosis of linear eruptions, clinicopathologic correlation is important for arriving at an accurate final diagnosis.

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“…In our case, as in other cases reported as 'acquired Blaschko dermatitis', there was no personal or family history of atopic dermatitis. Some authors suggested that these eruptions may present abortive forms of atopic dermatitis caused by mosaicism with one wild-type and one pathogenic allele in the affected Blaschko line and two wild-type alleles in the remaining tissues 2,8 . But so far the exact relationship still remains uncertain, so the term 'acquired Blaschko dermatitis' would be better in cases without systemic atopy.…”

Section: Discussionmentioning

confidence: 99%

“…The prognosis has a rapid resolution, less than 2 months and usually relapses are without sequelae. Histologically, a spongiotic pattern is characteristic 8 . In our case, clinical and histological features, except the unusual young age, fit acquired Blaschko dermatitis.…”

Section: Discussionmentioning

confidence: 99%

A Case of Acquired Blaschko Dermatitis in a Child; A Variant of Lichen Striatus, or Not?

et al. 2007

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Acquired Blaschko dermatitis is a rare inflammatory linear eruption that presents as multiple lines of itching papules and vesicles following the Blaschko's lines. Only ten cases have been reported in literatures since Grosshans' first description in 1990 and all cases have been in adults.A 2-year-old girl presented with a 4-month history of a slightly pruritic papulovesicular eruption, which was limited to the left side of her body, along the Blaschko's line. A skin biopsy revealed interface dermatitis. The eruption initially failed to respond to treatment with topical steroids but responded to systemic steroids. We present the first case of acquired Blaschko dermatitis in a child with a review of the relevant literature.

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Acquired Blaschkolinear dermatoses

Cited by 69 publications

References 12 publications

Lichen Planus Pigmentosus with Blaschkoid Distribution

Lichen Planus Pigmentosus with Blaschkoid Distribution

Interface dermatitis along Blaschko's lines

A Case of Acquired Blaschko Dermatitis in a Child; A Variant of Lichen Striatus, or Not?

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